Evidence map›Paper›PMID 34792221›Full record

ArticleClinical transplantation2022

Predictors and outcomes of respiratory failure among lung transplant patients with COVID-19.

Adrian Lawrence, Luke D Mahan, Manish R Mohanka, Srinivas Bollineni, Vaidehi Kaza, Ricardo M La Hoz, Song Zhang, Corey D Kershaw, Lance S Terada, Fernando Torres and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Clinical course of SARS-CoV-2 infection and recovery in lung transplant recipients.Transplant infectious disease : an official journal of the Transplantation Society · 2022
    Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Adrian LawrenceDivisions of Pulmonary and Critical Care Medicine, Dallas, Texas, USA.
Luke D MahanDivisions of Pulmonary and Critical Care Medicine, Dallas, Texas, USA.
Manish R MohankaDivisions of Pulmonary and Critical Care Medicine, Dallas, Texas, USA.
Srinivas BollineniDivisions of Pulmonary and Critical Care Medicine, Dallas, Texas, USA.
Vaidehi KazaDivisions of Pulmonary and Critical Care Medicine, Dallas, Texas, USA.ORCID 0000-0003-3578-6077
Ricardo M La HozInfectious Disease and Geographic Medicine, Dallas, Texas, USA.
Song ZhangDepartment of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Corey D KershawDivisions of Pulmonary and Critical Care Medicine, Dallas, Texas, USA.
Lance S TeradaDivisions of Pulmonary and Critical Care Medicine, Dallas, Texas, USA.
Fernando TorresDivisions of Pulmonary and Critical Care Medicine, Dallas, Texas, USA.
Amit BangaDivisions of Pulmonary and Critical Care Medicine, Dallas, Texas, USA.ORCID 0000-0002-6932-1537
Pulmonary and Critical Care Associates · USInfectious Disease Consultants · USThe University of Texas Southwestern Medical Center · US

Funding

TRAINING PROGRAM IN LUNG BIOLOGY AND DISEASET32HL098040 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI SHAUL, PHILIP W, TERADA, LANCE S · 2009 to 2024
$4.6M
(PQ1) Epigenetic effects of the premalignant fieldR01CA208620 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI TERADA, LANCE S · 2016 to 2020
$1.9M
NCI NIH HHS R01 CA208620NHLBI NIH HHS T32 HL098040
6 · The paper itself

Abstract

backgroundThere is limited data on the predictors and outcomes of new or worsening respiratory failure among lung transplant (LT) patients with Coronavirus disease 2019 (COVID-19).

methodsWe included all the LT patients diagnosed with COVID-19 during a 1-year period (March 2020 to February 2021; n = 54; median age: 60, 20-73 years; M:F 37:17). Development of new or worsening respiratory failure (ARF) was the primary outcome variable.

resultsThe overall incidence of ARF was 48.1% (n = 26). More than 20% of patients (n = 11) needed intubation and mechanical ventilation. Body mass index > 25 Kg/m

conclusionsCOVID-19 is associated with significant morbidity and mortality among LT patients. Patients on chronic anticoagulation seem to enjoy favorable outcomes, while higher BMI and peak D-dimer levels are associated with development of ARF. Pre-infection CLAD is associated with an increased risk of death from COVID-19.

Indexed as

COVID-19Lung TransplantationRespiratory InsufficiencyHumansRespiration, ArtificialSARS-CoV-2allograft dysfunctionanticoagulantscoagulationD-dimerSARS-CoV-2survival

Identifiers

PMID34792221
PMCPMC8646587
OpenAlexW3214175884

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.