Evidence map›Paper›PMID 34791781›Full record

ArticleHIV medicine2022

Follicle-stimulating hormone in postmenopausal women living with HIV: a prevalence study.

Shema Tariq, Hajra Okhai, Abigail Severn, Caroline A Sabin, Fiona Burns, Richard Gilson, Julie Fox, Yvonne Gilleece, Nicola E Mackie, Frank A Post and 5 more

Open access · hybridAbstract read
In one paragraph

Article in HIV medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 1 country.

Shema TariqUCL Institute for Global Health, London, UK.ORCID 0000-0001-9802-7727
Hajra OkhaiUCL Institute for Global Health, London, UK.ORCID 0000-0002-0549-4914
Abigail SevernUCL Institute for Global Health, London, UK.
Caroline A SabinUCL Institute for Global Health, London, UK.ORCID 0000-0001-5173-2760
Fiona BurnsUCL Institute for Global Health, London, UK.
Richard GilsonUCL Institute for Global Health, London, UK.
Julie FoxGuys and St Thomas NHS Foundation Trust, London, UK.
Yvonne GilleeceUniversity Hospitals Sussex NHS Trust, Brighton, UK.ORCID 0000-0002-9960-5389
Nicola E MackieImperial College Healthcare NHS Trust, London, UK.
Frank A PostKings College Hospital NHS Foundation Trust, London, UK.ORCID 0000-0002-2844-1612
Iain ReevesHomerton University Hospital NHS Foundation Trust, London, UK.
Melanie RosenvingeLewisham and Greenwich NHS Trust, London, UK.
Ann SullivanChelsea and Westminster NHS Foundation Trust, London, UK.
Andrew UstianowskiNorth Manchester General Hospital, Manchester University NHS Foundation Trust, Manchester, UK.
Robert F MillerUCL Institute for Global Health, London, UK.
The George Institute for Global Health · GBRoyal Free London NHS Foundation Trust · GBBrighton and Sussex Medical School · GBChelsea and Westminster Hospital NHS Foundation Trust · GBGuy's and St Thomas' NHS Foundation Trust · GBHomerton University Hospital NHS Foundation Trust · GBImperial College Healthcare NHS Trust · GBKing's College Hospital NHS Foundation Trust · GBLewisham and Greenwich NHS Trust · GBNorth Manchester General Hospital · GB

Funding

Department of Health
6 · The paper itself

Abstract

objectivesWe examined follicle-stimulating hormone (FSH) levels in women living with HIV aged > 45 reporting ≥ 12 months' amenorrhoea, and investigated correlation with menopausal symptoms.

methodsA cross-sectional substudy of 85 women from the Positive Transitions through the Menopause (PRIME) Study who reported irregular periods at entry into the PRIME Study and ≥ 12 months' amenorrhoea at recruitment into this substudy. Serum FSH was supplemented with clinical data and menopausal symptom assessment. Serum FSH > 30 mIU/mL was defined as consistent with postmenopausal status. Associations between FSH and menopausal symptom severity were assessed using Pearson's correlation and the Kruskal-Wallis test.

resultsMedian age was 53 years [interquartile range (IQR): 51-55]; all were on antiretroviral therapy, three-quarters (n = 65) had a CD4 T-cell count > 500 cells/μL and 91.8% (n = 78) had an HIV viral load (VL) < 50 copies/mL. Median FSH was 65.9 mIU/mL (IQR: 49.1-78.6). Only four women (4.7%) had FSH ≤ 30 mIU/mL; none reported smoking or drug use, all had CD4 T-cell count ≥ 200 cells/μL, and one had viral load (VL) ≥ 50 copies/mL. Median body mass index (BMI) was elevated compared with women with FSH > 30 mIU/mL (40.8 vs. 30.5 kg/m

conclusionsFour women in this small substudy had low FSH despite being amenorrhoeic; all had BMI ≥ 35 kg/m

Indexed as

Follicle Stimulating HormoneHIV InfectionsChild, PreschoolCross-Sectional StudiesEstradiolFemaleHumansMiddle AgedPostmenopauseEstradiolFollicle Stimulating Hormoneageingfollicle-stimulating hormoneHIVmenopausewomen

Identifiers

PMID34791781
PMCPMC9298721
OpenAlexW3213372603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.