Evidence map›Paper›PMID 34791757›Full record

ReviewJournal of cosmetic dermatology2022

Cutaneous and Allergic reactions due to COVID-19 vaccinations: A review.

Selami Aykut Temiz, Ayman Abdelmaksoud, Uwe Wollina, Omer Kutlu, Recep Dursun, Anant Patil, Torello Lotti, Mohamad Goldust, Michelangelo Vestita

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of cosmetic dermatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

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  14. Woman with pruritic rash and dermatographism.Journal of the American College of Emergency Physicians open · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 9 institutions in 7 countries.

Selami Aykut TemizDepartment of Dermatology, Konya Ereğli State Hospital, Konya, Turkey.ORCID https://orcid.org/0000-0003-4878-0045
Ayman AbdelmaksoudMansoura Dermatology, Venerology and Leprology Hospital, Mansoura, Egypt.ORCID https://orcid.org/0000-0003-4848-959X
Uwe WollinaDepartment of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital, Dresden, Germany.
Omer KutluDepartment of Dermatology, Tokat Gaziosmanpsa University, Tokat, Turkey.ORCID https://orcid.org/0000-0002-9665-015X
Recep DursunDepartment of Dermatology, Necmettin Erbakan University Meram Medical Faculty, Konya, Turkey.
Anant PatilDepartment of Pharmacology, Dr. DY Patil Medical College, Navi Mumbai, India.ORCID https://orcid.org/0000-0002-9455-4025
Torello LottiUniversity of Rome G. Marconi, Rome, Italy.
Mohamad GoldustDepartment of Dermatology, University Medical Center Mainz, Mainz, Germany.
Michelangelo VestitaUnit of Plastic and Reconstructive Surgery, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.
Brigham and Women's Hospital · USDr. D. Y. Patil Medical College, Hospital and Research Centre · INJohannes Gutenberg University Mainz · DEKonya Eğitim ve Araştırma Hastanesi · TRMansoura University Hospital · EGNecmettin Erbakan University · TRSechenov University · RUStädtisches Klinikum Dresden · DETokat Gaziosmanpaşa Üniversitesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe pandemic caused by the novel coronavirus disease 2019 (COVID-19) has had an unprecedented impact on the overall health and the global economy. Vaccination is currently the most dependable strategy to end the pandemic, despite the slower-than-hoped-for rollout, particularly for low-to-middle-income countries, and the uncertain duration of protection afforded by vaccination. The spike protein of the virus (immunodominant antigen of the virus) is the main target of the approved and candidate SARS-CoV-2 vaccines. This protein binds to the ACE2 receptor of the host cell, initiating the entry of the virus into the cell and the chain of subsequent events ending to Acute Respiratory Distress Syndrome. The safety profile of these vaccines needs is closely assessed.

methodsThis comprehensive review includes searching the PubMed, EMBASE, and Web of Science databases using the keywords "coronavirus", "COVID-19", "vaccine", "cutaneous reactions", "allergic reactions", and "SARS-CoV-2". Manual searching of reference lists of included articles augmented the research. The research was updated in June 2021.

resultsIn this narrative review, we tried to investigate and discuss the cutaneous and allergic reactions related to SARS-CoV-2 vaccines currently available in the literature. As a result, although COVID-19 vaccines can be reported to develop allergic and anaphylactic reactions, especially after m-RNA vaccines, they remain at a low rate, and it is observed that these reactions may develop more frequently, especially in patients with previous allergies and mast cell disorders. Fortunately, these reactions are generally transient, benign, self-limited.

conclusionAlthough there is still no definitive evidence, as dermatologists, we must be aware of the possibility of cutaneous reactions, newly diagnosed dermatoses, or exacerbation of existing dermatoses that may develop after the COVID-19 vaccinations.

Indexed as

COVID-19HypersensitivityCOVID-19 VaccinesHumansmRNA VaccinesVaccinationCOVID-19 VaccinesmRNA Vaccinesallergic reactionsBNT162b2COVID-19cutaneous reactionsSARS-CoV-2vaccination

Identifiers

PMID34791757
PMCPMC8661794
OpenAlexW3213650246

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.