ReviewChirality2022
ECD exciton chirality method today: a modern tool for determining absolute configurations.
Review in Chirality, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Homochiral Evolution from Self-Assembly of Chiral Block Copolymers.ACS macro letters · 2026Article
- Record Dissymmetry in Vibrational Optical Activity: Combining Vibronic Coupling and Aggregation in Cobalt(II) Camphorate Complexes.Angewandte Chemie (International ed. in English) · 2026Article
- Bifacial ladder polymers enabled by chirality-assisted synthesis that exhibit self-assembly and chirality-induced spin selectivity.Nature communications · 2026Article
- Exploring the Origin of Molecular Chirality: A Standalone Suite of Tools to Visualize and Analyze Transition Current Density.Journal of chemical theory and computation · 2026Article
- Chiroptics of In-Plane Excitons.The journal of physical chemistry. A · 2026Article
- From triangles to squares - chiral, overcrowded polyimine macrocycles of significant chiroptical response enable the capture of chlorinated solvents.Scientific reports · 2026Article
- Assigning the stereochemistry of natural products by machine learning.Journal of cheminformatics · 2026Article
- Synthesis, Structure, and Thin Film Optical Properties of a Chiral Benzothiazole-Derived Squaraine.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026Article
- Jorumycidine, a hexacyclic bis-tetrahydroisoquinoline alkaloid from marine symbiosis reveals new biosynthetic logic for anticancer design.Communications chemistry · 2026Article
- Advances in Natural Product Extraction: Established and Emerging Technologies.Molecules (Basel, Switzerland) · 2026Review
- Structure-Response Relationships in Rigid CChemphyschem : a European journal of chemical physics and physical chemistry · 2026Review
- Quantum Chemistry Calculations of Circularly Polarized Luminescence (CPL): From Spectral Modeling to Molecular Design.Chemical reviews · 2025Review
- Synthesis and Chiroptical Properties of Bithiophene-Functionalized Open and Methylene-Bridged Binaphthyl Derivatives.The Journal of organic chemistry · 2025Article
- Circular Dichroism and Multiphoton Circularly Polarized Luminescence Switching Using a Bis-perylene Diimide Macrocycle.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- The Discovery of Complex Heterocycles from Millipede Secretions.Journal of the American Chemical Society · 2025Article
- Boost of Chiroptical Responses Through the Enhancement of Electron Transition Dipole Moment.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Newly Isolated Aromatic Compounds from Ailanthus altissima and Their Anti-inflammatory Activity.ACS omega · 2025Article
- Chiral Induction of a Tetrakis(porphyrin) in Various Chiral Solvents.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- Exciting Novel Polyaspartates: Design, Synthesis, and Photo-Responsive Behavior in Solution and Lyotropic Liquid Crystalline Phase Upon Irradiation with Visible Light.Macromolecular rapid communications · 2024Article
- Chemical Constituents from the Fruit ofAntioxidants (Basel, Switzerland) · 2024Article
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Abstract
The application of the exciton chirality method (ECM) to interpret electronic circular dichroism (ECD) spectra is a well-established and still popular approach to assign the absolute configuration (AC) of natural products, chiral organic compounds, and organometallic species. The method applies to compounds containing at least two chromophores with electric dipole allowed transitions (e.g., π-π* transitions). The exciton chirality rule correlates the sign of an exciton couplet (two ECD bands with opposite sign and similar intensity) with the overall molecular stereochemistry, including the AC. A correct application of the ECM requires three main prerequisites: (a) the knowledge of the molecular conformation, (b) the knowledge of the directions of the electric transition moments (TDMs), and (c) the assumption that the exciton coupling mechanism must be the major source of the observed ECD signals. All these prerequisites can be easily verified by means of quantum-mechanical (QM) calculations. In the present review, we shortly introduce the general principles that underpin the use of the ECM for configurational assignments and survey its applications, both classic ones and some reported in the recent literature. Based on these examples, we will stress the advantages of the ECM but also the key requisites for its correct application. Additionally, we will discuss the dependence of the couplet sign on geometrical parameters (angles α,β,γ between TDMs), which can be helpful for discerning the sign of exciton chirality in ambiguous situations. Finally, we will present a molecular orbital (MO) description of the exciton coupling phenomenon.
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