ReviewAnnals of the New York Academy of Sciences2021
Noncoding RNAs: biology and applications-a Keystone Symposia report.
Erratum issuedAbstract readReview
In one paragraph
Review in Annals of the New York Academy of Sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Exosome-mediated decay of unstable long extended precursors of human telomerase RNA is dependent on 5'-cap trimethylation.Genes & development · 2026Article
- Epigenetic Changes in Alzheimer's Disease and Interventions for Therapy.Neuropsychiatric disease and treatment · 2026Review
- The Impact of Non-Coding RNA on Inflammation and Airway Remodeling in Asthma Related to Obesity: State-of-the-Art and Therapeutic Perspectives.Journal of clinical medicine · 2025Review
- Article
- Identifying small-molecules binding sites in RNA conformational ensembles with SHAMAN.Nature communications · 2024Article
- Regulatory RNAs: role as scaffolds assembling protein complexes and their epigenetic deregulation.Exploration of targeted anti-tumor therapy · 2024Review
- MANCR lncRNA Modulates Cell-Cycle Progression and Metastasis by Cis-Regulation of NuclearMolecular and cellular biology · 2024Article
- MicroRNAs: Small but Key Players in Viral Infections and Immune Responses to Viral Pathogens.Biology · 2023Review
- Role of miR‑181a‑5p in cancer (Review).International journal of oncology · 2023Review
- Spatial and temporal organization of the genome: Current state and future aims of the 4D nucleome project.Molecular cell · 2023Review
- Knockdown of LINC01087 inhibits gastric cancer malignant behavior by regulating the miR-135a-5p/CAAP1 axis.Functional & integrative genomics · 2023Article
- Pancreatic cancer stemness: dynamic status in malignant progression.Journal of experimental & clinical cancer research : CR · 2023Review
- Hyaluronan in the Cancer Cells Microenvironment.Cancers · 2023Review
- Innate Immunity in Cardiovascular Diseases-Identification of Novel Molecular Players and Targets.Journal of clinical medicine · 2023Review
- The Pol III transcriptome: Basic features, recurrent patterns, and emerging roles in cancer.Wiley interdisciplinary reviews. RNAReview
- Post-Transcriptional Regulation of Gene Expression and the Intricate Life of Eukaryotic mRNAs.Wiley interdisciplinary reviews. RNAReview
Corrections and comments
- Erratum issuedErratum for.2022
Authors and funding
39 authors.
Jennifer CablePhD Science Writer, New York, New York.
Edith HeardEuropean Molecular Biology Laboratory (EMBL), Heidelberg, Heidelberg, Germany.
Tetsuro HiroseGraduate School of Frontier Biosciences, Osaka University, Suita, Japan.
Kannanganattu V PrasanthDepartment of Cell and Developmental Biology, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Ling-Ling ChenState Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of the Chinese Academy of Sciences, Shanghai, China.
Jonathan E HenningerWhitehead Institute for Biomedical Research, Cambridge, Massachusetts.
Sofia A QuinodozDepartment of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey.
David L SpectorCold Spring Harbor Laboratory, Cold Spring Harbor and Genetics Program, Stony Brook University, Stony Brook, New York.
Sarah D DiermeierDepartment of Biochemistry, University of Otago, Dunedin, New Zealand.
Allison M PormanBiochemistry and Molecular Genetics Department, University of Colorado, Anschutz Medical Campus, Aurora, Colorado.
Dhiraj KumarDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Mark W FeinbergCardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Xiaohua ShenTsinghua-Peking Joint Center for Life Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing, China.
Juan Pablo UnfriedCenter for Applied Medical Research (CIMA), Department of Gene Therapy and Regulation of Gene Expression, Universidad de Navarra (UNAV), Pamplona, Spain.
Rory JohnsonDepartment of Medical Oncology, Inselspital, Bern University Hospital; and Department for BioMedical Research University of Bern, Bern, Switzerland.
Chun-Kan ChenCenter for Personal Dynamic Regulomes, Stanford University, Stanford, California.
Jeremy E WiluszDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Adelheid LempradlDepartment of Metabolism and Nutritional Programming, Van Andel Research Institute, Grand Rapids, Michigan.
Sean E McGearyWhitehead Institute for Biomedical Research, Cambridge, Massachusetts.
Lamia WahbaDepartment of Genetics, Stanford University School of Medicine, Stanford, California.
Anna Marie PyleDepartment of Genetics, Yale School of Medicine, New Haven, Connecticut.
Amanda E HargroveDepartment of Chemistry, Duke University, Durham, North Carolina.
Matthew D SimonDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut.
Marco MarciaEuropean Molecular Biology Laboratory (EMBL) Grenoble, Grenoble, France.
Róża K PrzanowskaDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia.
Howard Y ChangCenter for Personal Dynamic Regulomes, Stanford University, Stanford, California.
Samie R JaffreyDepartment of Pharmacology, Weill Medical College of Cornell University, New York, New York.
Lydia M ContrerasMcKetta Department of Chemical Engineering, University of Texas at Austin, Austin, Texas.
Qi ChenDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, California.
Junchao ShiDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, California.
Joshua T MendellDepartment of Molecular Biology, Harold C. Simmons Comprehensive Cancer Center, Hamon Center for Regenerative Science and Medicine; and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas.
Lin HeDivision of Cellular and Developmental Biology, Molecular and Cell Biology Department, University of California at Berkeley, Berkeley, California.
Erwei SongGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center and Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University; Bioland Laboratory; Program of Molecular Medicine, Zhongshan School of Medicine, Sun Yat-sen University; and Fountain-Valley Institute for Life Sciences, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences Guangzhou, Guangzhou, China.
John L RinnDepartment of Biochemistry, BioFrontiers Institute, and Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, Colorado.
Mukesh Kumar LalwaniQueens Medical Research Institute, BHF Centre for Cardiovascular Sciences, University of Edinburgh, Scotland, United Kingdom.
Murat Can KalemDepartment of Microbiology and Immunology, Witebsky Center for Microbial Pathogenesis and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, New York.
Edward B ChuongDepartment of Molecular, Cellular, and Developmental Biology and BioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado.
Lynne E MaquatDepartment of Biochemistry and Biophysics, School of Medicine and Dentistry and Center for RNA Biology, University of Rochester, Rochester, New York.
Xuhang LiuLaboratory of Systems Cancer Biology, The Rockefeller University, New York, New York.
Funding
New mechanisms and technologies for understanding post-transcriptional gene regulation in neuronsR35NS111631 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI SAMIE R JAFFREY · 2019 to 2026
$8.6MRegulatory roles for the Integrator complex and circular RNAsR35GM119735 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI WILUSZ, JEREMY E · 2016 to 2025
$4.1MMolecular Mechanisms underlying tRNA-fragment regulation of cancerR01CA215491 · NCI · ROCKEFELLER UNIVERSITY · PI TAVAZOIE, SOHAIL F. · 2017 to 2021
$2.3MCharacterization of nuclear-retained RNA-mediated gene regulatory mechanismsR01GM132458 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KANNANGANATTU, PRASANTH KUMAR VIJAYAN · 2020 to 2023
$1.4MMonoalleleic autosomal spreading of a novel family of nucleolus-localized ncRNAsR21AG065748 · NIA · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KANNANGANATTU, PRASANTH KUMAR VIJAYAN · 2020 to 2021
$423kLong non-coding RNA Heterogeneity in ER + Breast CancerK00CA253732 · NCI · UNIVERSITY OF VIRGINIA · PI PRZANOWSKA, ROZA KAMILA · 2021 to 2024
$400kLong non-coding RNAs as novel therapeutic targets in gliomas treatmentF99CA253732 · NCI · UNIVERSITY OF VIRGINIA · PI PRZANOWSKA, ROZA KAMILA · 2020 to 2020
$36kNCI NIH HHS F99 CA253732NCI NIH HHS K00 CA253732NCI NIH HHS R01 CA215491NIA NIH HHS R21 AG065748NIGMS NIH HHS R01 GM132458NIGMS NIH HHS R35 GM119735NINDS NIH HHS R35 NS111631
Abstract
The human transcriptome contains many types of noncoding RNAs, which rival the number of protein-coding species. From long noncoding RNAs (lncRNAs) that are over 200 nucleotides long to piwi-interacting RNAs (piRNAs) of only 20 nucleotides, noncoding RNAs play important roles in regulating transcription, epigenetic modifications, translation, and cell signaling. Roles for noncoding RNAs in disease mechanisms are also being uncovered, and several species have been identified as potential drug targets. On May 11-14, 2021, the Keystone eSymposium "Noncoding RNAs: Biology and Applications" brought together researchers working in RNA biology, structure, and technologies to accelerate both the understanding of RNA basic biology and the translation of those findings into clinical applications.
Indexed as
Research ReportAnimalsCongresses as TopicDrug Delivery SystemsEpigenesis, GeneticGene TargetingHumansMicroRNAsRNA, Long NoncodingRNA, Small InterferingRNA, Small UntranslatedRNA, UntranslatedSignal TransductionMicroRNAsRNA, Long NoncodingRNA, Small InterferingRNA, Small UntranslatedRNA, UntranslatedcircRNAlncRNAnoncoding RNAnuclear condensatephase transitionpiRNAtranscriptionXist
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.