Evidence map›Paper›PMID 34791588›Full record

Observational studyJournal of assisted reproduction and genetics2022

MUM-1 immunohistochemistry has high accuracy and reliability in the diagnosis of chronic endometritis: a multi-centre comparative study with CD-138 immunostaining.

Ettore Cicinelli, Sergio Haimovich, Dominique De Ziegler, Nili Raz, Dana Ben-Tzur, Alessandra Andrisani, Guido Ambrosini, Nico Picardi, Viviana Cataldo, Marco Balzani and 9 more

Open access · greenAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of assisted reproduction and genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 4 countries.

Ettore CicinelliDepartment of Biomedical and Human Oncological Science (DIMO), 2nd Unit of Obstetrics and Gynecology, University of Bari, Policlinico, Piazza Giulio Cesare 11, 70124, Bari, Italy.
Sergio HaimovichDepartment of Obstetrics and Gynecology, Hospital del Mar, Autonomous University of Barcelona, Barcelona, Spain.
Dominique De ZieglerDepartment of Gynaecology Obstetrics II and Reproductive Medicine, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Universitaire Paris Centre, Centre Hospitalier Universitaire (CHU) Cochin, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Nili RazDepartment of Obstetrics and Gynecology, Hillel Yaffe Medical Center, Hadera. The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Hadera, Israel.
Dana Ben-TzurDepartment of Obstetrics and Gynecology, Hillel Yaffe Medical Center, Hadera. The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Hadera, Israel.
Alessandra AndrisaniDepartment of Women's and Children's Health, University of Padua, via Nicolò Giustiniani 3, 35128, Padua, Italy.
Guido AmbrosiniDepartment of Women's and Children's Health, University of Padua, via Nicolò Giustiniani 3, 35128, Padua, Italy.
Nico PicardiDepartment of Biomedical and Human Oncological Science (DIMO), 2nd Unit of Obstetrics and Gynecology, University of Bari, Policlinico, Piazza Giulio Cesare 11, 70124, Bari, Italy.
Viviana CataldoDepartment of Biomedical and Human Oncological Science (DIMO), 2nd Unit of Obstetrics and Gynecology, University of Bari, Policlinico, Piazza Giulio Cesare 11, 70124, Bari, Italy.
Marco BalzaniDepartment of Biomedical and Human Oncological Science (DIMO), 2nd Unit of Obstetrics and Gynecology, University of Bari, Policlinico, Piazza Giulio Cesare 11, 70124, Bari, Italy.
Rossana CicinelliDepartment of Biomedical and Human Oncological Science (DIMO), 2nd Unit of Obstetrics and Gynecology, University of Bari, Policlinico, Piazza Giulio Cesare 11, 70124, Bari, Italy.
Marco NoventaDepartment of Women's and Children's Health, University of Padua, via Nicolò Giustiniani 3, 35128, Padua, Italy.
Loris MarinDepartment of Women's and Children's Health, University of Padua, via Nicolò Giustiniani 3, 35128, Padua, Italy.
Pantaleo GrecoSection of Gynecology and Obstetrics, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Leonardo RestaInstitute of Pathology, Faculty of Medicinecs, University of Bari, Bari, Italy.
Carlo SaccardiDepartment of Women's and Children's Health, University of Padua, via Nicolò Giustiniani 3, 35128, Padua, Italy.
Giovanni BuzzaccariniDepartment of Women's and Children's Health, University of Padua, via Nicolò Giustiniani 3, 35128, Padua, Italy. giovanni.buzzaccarini@gmail.com.ORCID http://orcid.org/0000-0002-9466-0178
Amerigo VitaglianoDepartment of Women's and Children's Health, University of Padua, via Nicolò Giustiniani 3, 35128, Padua, Italy.
International Working Group for Standardization of Chronic Endometritis Diagnosis
University of Padua · ITUniversity of Bari Aldo Moro · ITHillel Yaffe Medical Center · ILUniversitat Autònoma de Barcelona · ESUniversité Paris Cité · FRUniversity of Ferrara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe current gold standard for chronic endometritis (CE) diagnosis is immunohistochemistry (IHC) for CD-138. However, IHC for CD-138 is not exempt from diagnostic limitations. The aim of our study was to evaluate the reliability and accuracy of MUM-1 IHC, as compared with CD-138.

methodsThis is a multi-centre, retrospective, observational study, which included three tertiary hysteroscopic centres in university teaching hospitals. One hundred ninety-three consecutive women of reproductive age were referred to our hysteroscopy services due to infertility, recurrent miscarriage, abnormal uterine bleeding, endometrial polyps or myomas. All women underwent hysteroscopy plus endometrial biopsy. Endometrial samples were analysed through histology, CD138 and MUM-1 IHC. The primary outcome was to evaluate the diagnostic accuracy of MUM-1 IHC for CE, as compared with CD-138 IHC.

resultsSensitivity and specificity of CD-138 and MUM-1 IHC were respectively 89.13%, 79.59% versus 93.48% and 85.03%. The overall diagnostic accuracy of MUM-1 and CD-138 IHC were similar (AUC = 0.893 vs AUC = 0.844). The intercorrelation coefficient for single measurements was high between the two techniques (ICC = 0.831, 0.761-0.881 95%CI). However, among CE positive women, MUM-1 allowed the identification of higher number of plasma cells/hpf than CD-138 (6.50 [SD 4.80] vs 5.05 [SD 3.37]; p = 0.017). Additionally, MUM-1 showed a higher inter-observer agreement as compared to CD-138.

conclusionIHC for MUM-1 and CD-138 showed a similar accuracy for detecting endometrial stromal plasma cells. Notably, MUM-1 showed higher reliability in the paired comparison of the individual samples than CD-138. Thus, MUM-1 may represent a novel, promising add-on technique for the diagnosis of CE.

Indexed as

AdultBiomarkersEndometritisFemaleHumansImmunohistochemistryInterferon Regulatory Factor-4Interferon Regulatory FactorsReproducibility of ResultsRetrospective StudiesSpainSyndecan-1BiomarkersInterferon Regulatory Factor-4Interferon Regulatory FactorsSDC1 protein, humanSyndecan-1CD138Chronic endometritisDiagnostic accuracyMUM-1Plasma cells

Identifiers

PMID34791588
PMCPMC8866577
OpenAlexW3212228442

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.