ArticleEuropean journal of clinical pharmacology2022
Trends in the use of oral anticoagulants, antiplatelets and statins in four European countries: a population-based study.
Article in European journal of clinical pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of statin use on survival and adverse events in patients with cancer receiving radiotherapy: a systematic review and meta-analysis.BMC cancer · 2025Pooled it
- Medication changes and potentially inappropriate prescribing in older patients with significant polypharmacy.International journal of clinical pharmacy · 2023Trial
- Long-Term Proton Pump Inhibitor Therapy Is Common Among Older Adults: An 8-Year Finnish Nationwide Register Study.Drugs & aging · 2026Article
- Postbleeding antithrombotic management in cardiovascular patients: insights from the Attica Bleeding Snapshot study.Research and practice in thrombosis and haemostasis · 2026Observational
- Minimal head injury in asymptomatic patients on antithrombotic therapy: is in-hospital observation justified after an initial normal computed tomography scan?Internal and emergency medicine · 2026Article
- Development of a nomogram for prediction of postoperative bleeding after transurethral resection of bladder tumors.International urology and nephrology · 2026Article
- Can drug-induced platelet dysfunction be reversed?Research and practice in thrombosis and haemostasis · 2026Review
- Gross haematuria in the era of anticoagulant therapy - Implications on treatment and diagnostic approaches in a large emergency department patient population.BJUI compass · 2025Article
- National survey of current practices and attitudes regarding discharge disposition for older adults with mild traumatic brain injury and traumatic intracranial hemorrhage.Acta neurologica Belgica · 2025Article
- Effect of acipimox on skeletal muscle biochemistry, structure and function in older people with probable sarcopenia: an experimental medicine study.GeroScience · 2025Article
- Trends in Lipid-Lowering Agent Consumption in Croatia: A 25-Year Observational Study.Pharmacology research & perspectives · 2025Observational
- Regular Use of Oral Nonsteroidal Anti-inflammatory Drugs in a Population of Polish Seniors: Findings from the PolSenior2 Cross-Sectional Survey.Drugs & aging · 2025Article
- Causes of death and trends in mortality from the year 2000 to 2017 in patients with acute myocardial infarction.Annals of medicine · 2024Article
- How to undertake procedures while on antiplatelet agents: a hematologist's view.Research and practice in thrombosis and haemostasis · 2024Review
- Quality Control and Safety Assessment of Online-Purchased Food Supplements Containing Red Yeast Rice (RYR).Foods (Basel, Switzerland) · 2024Article
- Antithrombotic Use Patterns in COVID-19 Patients from Spain: A Real-World Data Study.Journal of clinical medicine · 2024Article
- National Trends in the Use of State-Reimbursed Lipid-Lowering Medications in Latvia (2012-2021).Journal of clinical medicine · 2023Article
- Management and Prognosis of Acute Stroke in Atrial Fibrillation.Journal of clinical medicine · 2023Review
- Article
- Antiplatelets and Anticoagulants in Vitreoretinal Surgery: A Systematic Review.Life (Basel, Switzerland) · 2023Review
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Authors and funding
11 authors.
Funding
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Abstract
purposeTo evaluate time trends in the prevalence of antithrombotic and statin use in four European countries.
methodsUsing population-based data from the United Kingdom, Denmark, Spain and Italy between 2010 and 2018, we calculated standardized annual prevalence proportions of antithrombotics and statin use, and changes in prevalence proportions (2018 vs. 2010).
resultsPrevalence proportion of statins increased from 24.8% to 24.6% (UK), 21.0% to 22.3% (Region of Southern Denmark [RSD]), 12.9% to 14.3% (Udine, Italy), and 20.3% to 23.2% (Spain). Prevalence proportions of antithrombotics declined in all four countries: 18.7% to 15.9% (UK; - 2.8% points), 18.9% to 18.1% (RSD; - 0.8% points), 17.7% to 16.6% (Udine; - 1.1% points) and 15.0% to 13.6% (Spain; - 1.4% points). These declines were driven by reductions in low-dose aspirin use: 15.3% to 8.9% (UK; - 6.4% points), 16.3% to 9.5% (RSD; - 6.8% points), 13.5% to 11.6% (Udine; - 1.9% points), and 10.2% to 8.8% (Spain; - 1.4% points). In the UK, low-dose aspirin use declined from 9.1% to 4.3% (- 4.8% points) for primary CVD prevention, and from 49.6% to 36.9% (- 12.7% points) for secondary prevention. Oral anticoagulant use gradually increased but did not fully account for the decrease in low-dose aspirin use.
conclusionsAntithrombotic use in the UK, RSD, Udine and Spain declined between 2010 and 2018, driven by a reduction in use of low-dose aspirin that is not completely explained by a gradual increase in OAC use. Use of statins remained constant in the UK, and increased gradually in the RSD, Udine and Spain.
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