Evidence map›Paper›PMID 34791518›Full record

ArticleJournal of neurology2022

The role of frailty in Parkinson's disease: a cross-sectional study.

Daniele Belvisi, Marco Canevelli, Matteo Costanzo, Margherita Giangrosso, Andrea Fabbrini, Andrea Borraccino, Giuseppe Bruno, Alfredo Berardelli, Giovanni Fabbrini

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Frailty in Parkinson's disease: time to integrate it into treatment decision-making?Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  2. Article
  3. Article
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  5. Review
  6. Frailty and hospital outcomes among patients with neurological disorders.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  7. Observational
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  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Daniele Belvisi *Department of Human Neuroscience, Sapienza University of Rome, Viale dell'Università 30, 00185, Rome, Italy.
Marco Canevelli *Department of Human Neuroscience, Sapienza University of Rome, Viale dell'Università 30, 00185, Rome, Italy.
Matteo CostanzoDepartment of Human Neuroscience, Sapienza University of Rome, Viale dell'Università 30, 00185, Rome, Italy.
Margherita GiangrossoDepartment of Human Neuroscience, Sapienza University of Rome, Viale dell'Università 30, 00185, Rome, Italy.
Andrea FabbriniDepartment of Human Neuroscience, Sapienza University of Rome, Viale dell'Università 30, 00185, Rome, Italy.
Andrea BorraccinoDepartment of Human Neuroscience, Sapienza University of Rome, Viale dell'Università 30, 00185, Rome, Italy.
Giuseppe BrunoDepartment of Human Neuroscience, Sapienza University of Rome, Viale dell'Università 30, 00185, Rome, Italy.
Alfredo BerardelliDepartment of Human Neuroscience, Sapienza University of Rome, Viale dell'Università 30, 00185, Rome, Italy.
Giovanni FabbriniDepartment of Human Neuroscience, Sapienza University of Rome, Viale dell'Università 30, 00185, Rome, Italy. giovanni.fabbrini@uniroma1.it.
Sapienza University of Rome · ITIstituto Neurologico Mediterraneo · ITNational Institute of Health · AM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFrailty is an age-related state of increased risk for health-related adverse outcomes that reflects multisystem physiological changes and likely influences the clinical expression and disease progression of neurodegenerative disorders. The aim of the present study was to assess the potential relationship between frailty, as assessed by a frailty index (FI), and motor symptom severity, motor subtypes, and non-motor domains in Parkinson's disease (PD).

methodsWe consecutively enrolled 150 PD patients. We administered an FI specifically designed for PD that included 50 age-related multidimensional biological deficits. Patients underwent a clinical assessment that evaluated motor and non-motor manifestations of PD. Using the FI score, we classified PD patients as relatively fit (FI ≤ 0.10), less fit (0.10 < FI ≤ 0.21), or frail (FI > 0.21). A linear regression model was designed to explore possible associations between frailty level and PD motor and non-motor manifestations.

resultsFrail patients showed greater motor symptom severity and motor complications than fitter patients. A trend towards a higher prevalence of the postural instability/gait disorder subtype was also observed in frail versus relatively fit and less fit patients. The global burden of non-motor symptoms was higher in frail patients. Increased frailty was associated with more severe motor and non-motor symptoms, as well as with more pronounced cognitive deficits. These associations remained significant even when "traditional" predictors of PD severity (age, disease duration, and levodopa equivalent daily dose) were considered.

conclusionsThe present findings indicate that the FI is associated with both motor and non-motor features of PD.

Indexed as

FrailtyParkinson DiseaseCross-Sectional StudiesHumansLevodopaSeverity of Illness IndexLevodopaFrailty indexMotor symptomsNon-motor symptomsParkinson’s diseaseSubtypes

Identifiers

PMID34791518
OpenAlexW3211561304

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.