Evidence map›Paper›PMID 34791487›Full record

ArticleSleep2022

Napping behavior in adults with episodic migraine: a six-week prospective cohort study.

Angeliki Vgontzas, Elizabeth Mostofsky, Kobina Hagan, Michael Rueschman, Murray A Mittleman, Suzanne M Bertisch

Open access · bronzeAbstract read
In one paragraph

Article in Sleep, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Sleep and Headache Disorders: What a Clinician Needs to Know.Current neurology and neuroscience reports · 2026
    Review
  2. The effect of standard time to daylight-saving clock transition on sleep and migraine headaches.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
    Observational
  3. Sleep Symptoms in Migraine.Current neurology and neuroscience reports · 2024
    Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Angeliki VgontzasDepartment of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Elizabeth MostofskyDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Kobina HaganDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0003-4964-1880
Michael RueschmanProgram in Sleep Medicine Epidemiology, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-0506-8368
Murray A MittlemanHarvard Medical School, Boston, MA, USA.
Suzanne M BertischHarvard Medical School, Boston, MA, USA.
Brigham and Women's Hospital · USBeth Israel Deaconess Medical Center · USHarvard University · US

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
Alcohol and Breast Cancer: Genetic Interactions and Effects on Aromatase Inhibitor TherapyK01AA027831 · NIAAA · HARVARD SCHOOL OF PUBLIC HEALTH · PI MOSTOFSKY, ELIZABETH · 2019 to 2023
$820k
Short Sleep Duration and Sleep Disturbance as a Trigger of MigraineR21NS091627 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI BERTISCH, SUZANNE · 2015 to 2016
$498k
NIAAA NIH HHS K01 AA027831NIH HHS UL 1TR002541NINDS NIH HHS R21 NS091627
6 · The paper itself

Abstract

STUDY

objectivesPatients with migraine commonly endorse napping as a strategy for headache pain relief, but also experience high rates of sleep disturbance. To elucidate the relationship between napping behavior and migraine, we evaluated the association between napping and headache frequency, severity, and intensity among adults with episodic migraine. We also examined the association between daily napping and that night's sleep.

methodsIn this six-week prospective cohort study, 97 adults with episodic migraine completed twice-daily headache and sleep electronic diaries and wore a wrist actigraph. We modeled the associations between napping (yes/no) and headaches with conditional logistic regression and daily napping and nighttime sleep with linear regression.

resultsOver 4,353 study days, participants reported 1,059 headache days and 389 days with naps. More than 80% of participants napped during the study, with mean nap duration of 76.7 ± 62.4 min. Naps were more likely to occur on day 2 of headache 35/242 (14.5%) than on nonheadache days 279/3294 (8.5%, OR 2.2 [95% CI 1.4, 3.4]). Mean nap onset time (14:40 ± 3.3 h) was later than headache onset (12:48 ± 5.3 h). In adjusted models, napping was associated with an additional 1.1 (95% CI -1.4, 3.6) headache days/month. Naps were not associated with worse self-reported or objective sleep that night.

conclusionsOur findings suggest that naps may be an uncommonly used behavioral strategy for prolonged migraine attacks and do not contribute to nightly sleep disturbance. Future studies are needed to examine the acute analgesic effects of daytime napping in patients with migraine.

Indexed as

Migraine DisordersSleep Wake DisordersAdultHumansLogistic ModelsProspective StudiesSleepcohortmigrainenappingsleep

Identifiers

PMID34791487
PMCPMC8919195
OpenAlexW3214723756

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.