ArticlePlant physiology2022
Vacuolar H+-pyrophosphatase HVP10 enhances salt tolerance via promoting Na+ translocation into root vacuoles.
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 52 citations in OpenAlex.
- OsNAC10 negatively regulates salt tolerance by repressing OsHKT1;5 expression and reducing shoot-to-root NaPlant communications · 2026Article
- Transcription factor HvDREB4.1 and HvDREB4.2 from Hulless barley enhance tolerance to drought and salt stress in transgenic Arabidopsis thaliana.BMC plant biology · 2026Article
- Divergent Roles ofPlants (Basel, Switzerland) · 2026Article
- Differential Regulation of Gene Expression, Ion Homeostasis, and Antioxidant Defense Confers Salinity Tolerance During Seed Germination in Wheat.Plants (Basel, Switzerland) · 2026Article
- Overexpression ofGM crops & food · 2025Article
- Genome-Wide Identification of thePlants (Basel, Switzerland) · 2025Article
- Genome-Wide Identification, Characterization, and Comparison ofPlants (Basel, Switzerland) · 2025Article
- Ion homeostasis and coordinated salt tolerance mechanisms in a barley (Hordeum vulgare L.)doubled haploid line.BMC plant biology · 2025Article
- Systematic identification of sugarcane vacuolar HPlant cell reports · 2024Article
- Efficient gene editing of a model fern species through gametophyte-based transformation.Plant physiology · 2024Article
- Advances in genomic tools for plant breeding: harnessing DNA molecular markers, genomic selection, and genome editing.Biological research · 2024Review
- Overexpression of vacuolar HFrontiers in plant science · 2024Article
- Unravelling drought and salinity stress responses in barley genotypes: physiological, biochemical, and molecular insights.Frontiers in plant science · 2024Article
- Applying microbial biostimulants and drought-tolerant genotypes to enhance barley growth and yield under drought stress.Frontiers in plant science · 2024Review
- Genome-Wide Identification and Expression Analysis of the Stearoyl-Acyl Carrier Protein Δ9 Desaturase Gene Family under Abiotic Stress in Barley.International journal of molecular sciences · 2023Article
- Genetic resources and precise gene editing for targeted improvement of barley abiotic stress tolerance.Journal of Zhejiang University. Science. B · 2023Review
- Plants' Response Mechanisms to Salinity Stress.Plants (Basel, Switzerland) · 2023Review
- The Potential of CRISPR/Cas Technology to Enhance Crop Performance on Adverse Soil Conditions.Plants (Basel, Switzerland) · 2023Review
- HvNCX, a prime candidate gene for the novel qualitative locus qS7.1 associated with salinity tolerance in barley.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Engineering drought and salinity tolerance traits in crops through CRISPR-mediated genome editing: Targets, tools, challenges, and perspectives.Plant communications · 2022Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vacuolar H+-pumping pyrophosphatases (VPs) provide a proton gradient for Na+ sequestration in the tonoplast; however, the regulatory mechanisms of VPs in developing salt tolerance have not been fully elucidated. Here, we cloned a barley (Hordeum vulgare) VP gene (HVP10) that was identified previously as the HvNax3 gene. Homology analysis showed VP10 in plants had conserved structure and sequence and likely originated from the ancestors of the Ceramiales order of Rhodophyta (Cyanidioschyzon merolae). HVP10 was mainly expressed in roots and upregulated in response to salt stress. After salt treatment for 3 weeks, HVP10 knockdown (RNA interference) and knockout (CRISPR/Cas9 gene editing) barley plants showed greatly inhibited growth and higher shoot Na+ concentration, Na+ transportation rate and xylem Na+ loading relative to wild-type (WT) plants. Reverse transcription quantitative polymerase chain reaction and microelectronic Ion Flux Estimation results indicated that HVP10 likely modulates Na+ sequestration into the root vacuole by acting synergistically with Na+/H+ antiporters (HvNHX1 and HvNHX4) to enhance H+ efflux and K+ maintenance in roots. Moreover, transgenic rice (Oryza sativa) lines overexpressing HVP10 also showed higher salt tolerance than the WT at both seedling and adult stages with less Na+ translocation to shoots and higher grain yields under salt stress. This study reveals the molecular mechanism of HVP10 underlying salt tolerance and highlights its potential in improving crop salt tolerance.
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