Evidence map›Paper›PMID 34791412›Full record

ArticleMilitary medicine2022

Optimizing the Impact of Pragmatic Clinical Trials for Veteran and Military Populations: Lessons From the Pain Management Collaboratory.

Joseph Ali, Margaret Antonelli, Lori Bastian, William Becker, Cynthia A Brandt, Diana J Burgess, Amy Burns, Steven P Cohen, Alison F Davis, Christopher L Dearth and 37 more

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Military medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05097521 (Complementary and Integrative Health for Pain in the VA), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05097521 completednot on this map

Complementary and Integrative Health for Pain in the VA: A National Demonstration Project (NIH-VA-DOD Joint Initiative)

TypeobservationalSponsorVA Office of Research and DevelopmentRan2021 to 2023Enrolled3,603ConditionsChronic Musculoskeletal PainArmsPractitioner-delivered CIH therapies, Combination of practitioner-delivered and self-care CIH therapies, Self-care CIH therapies
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

47 authors at 20 institutions in 1 country.

Joseph AliJohns Hopkins Berman Institute of Bioethics and Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Margaret AntonelliVA Connecticut Healthcare System, West Haven, CT 06516, USA.
Lori BastianVA Connecticut Healthcare System, West Haven, CT 06516, USA.
William BeckerVA Connecticut Healthcare System, West Haven, CT 06516, USA.
Cynthia A BrandtVA Connecticut Healthcare System, West Haven, CT 06516, USA.
Diana J BurgessMinneapolis VA Health Care System, Minneapolis, MN 55417, USA.
Amy BurnsVA Connecticut Healthcare System, West Haven, CT 06516, USA.
Steven P CohenJohns Hopkins Medical Institutions, Clarksville, MD 21029, USA0.
Alison F DavisYale University School of Medicine, New Haven, CT 06520, USA.
Christopher L DearthDoD-VA Extremity Trauma and Amputation Center of Excellence, Bethesda, MD 20814, USA.
Jim DziuraYale University School of Medicine, New Haven, CT 06520, USA.
Rob EdwardsDepartment of Anesthesiology, Harvard Medical School, Brigham and Women's Hospital, Chestnut Hill, MA 02467, USA.
Joe ErdosVA Connecticut Healthcare System, West Haven, CT 06516, USA.
Shawn FarrokhiNaval Medical Center San Diego, Department of Physical Therapy, San Diego, CA 92134, USA.
Julie FritzUniversity of Utah, College of Health, Salt Lake City, UT 84108, USA.
Mary GedaYale University School of Medicine, New Haven, CT 06520, USA.
Steven Z GeorgeDuke Clinical Research Institute and Department of Orthopaedic Surgery, Duke University, Durham, NC 27715, USA.
Christine GoertzSpine IQ, Oskaloosa, IA 52577, USA.
Jeffrey GoodieSchool of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Susan N HastingsDuke University School of Medicine, Durham, NC 27710, USA.
Alicia HeapyVA Connecticut Healthcare System, West Haven, CT 06516, USA.
Brian M IlfeldDepartment of Anesthesiology, University of California San Diego School of Medicine, LaJolla, CA 92093, USA.
Lily KatsovichYale University School of Medicine, New Haven, CT 06520, USA.
Robert D KernsVA Connecticut Healthcare System, West Haven, CT 06516, USA.ORCID 0000-0002-3834-973X
Tassos C KyriakidesVA Connecticut Healthcare System, West Haven, CT 06516, USA.
Allison LeeVA Connecticut Healthcare System, West Haven, CT 06516, USA.
Cynthia R LongPalmer Center for Chiropractic Research, Davenport, IA 52803, USA.
Stephen L LutherJames A. Haley Veterans Hospital, Tampa, FL 33612, USA.
Steve MartinoVA Connecticut Healthcare System, West Haven, CT 06516, USA.
Michael E MathenyTennessee Valley Healthcare System, Nashville, TN 37212, USA.
Don McGearyDepartment of Psychiatry & Behavioral Sciences, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Amanda MidboeVA Palo Alto Health Care System, Palo Alto, CA 94304, USA.
Paul PasquinaDepartment of Physical Medicine & Rehabilitation, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Peter PeduzziYale University School of Medicine, New Haven, CT 06520, USA.
Michael RaffanelloVA Connecticut Healthcare System, West Haven, CT 06516, USA.
Daniel RhonBrooke Army Medical Center, JBSA Fort Sam Houston, TX 78234, USA.
Marc RosenVA Connecticut Healthcare System, West Haven, CT 06516, USA.
Elizabeth Russell EspositoVA Puget Sound Health Care System, Seattle, WA 98108, USA.
Dylan ScartonHenry Jackson Foundation, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Susan N HastingsDurham VA Medical Center, Durham, NC 27701, USA.
Karen SealUniversity of California San Francisco, School of Medicine, San Francisco, CA 94143, USA.
Norman SillikerYale University School of Medicine, New Haven, CT 06520, USA.
Sakasha TaylorVA Connecticut Healthcare System, West Haven, CT 06516, USA.
Stephanie L TaylorVA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA.
Megan TsuiHenry Jackson Foundation, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Fred S WrightVA Connecticut Healthcare System, West Haven, CT 06516, USA.
Steven ZeliadtVA Puget Sound Health Care System, Seattle, WA 98108, USA.
Yale University · USUniformed Services University of the Health Sciences · USDuke University · USJohns Hopkins University · USUniversity of California, Los Angeles · USVA Connecticut Healthcare System · USBrigham and Women's Hospital · USBrooke Army Medical Center · USMinneapolis VA Health Care System · USNaval Medical Center San Diego · USPalmer College of Chiropractic · USSan Francisco VA Medical Center · USThe University of Texas Health Science Center at San Antonio · USUniversity of California San Diego · USUniversity of South Florida · USUniversity of Utah · USUniversity of Washington · USVA Palo Alto Health Care System · USVA Puget Sound Health Care System · USVA Tennessee Valley Healthcare System · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Pain Management Collaboratory Coordinating Center (PMC3)U24AT009769 · NCCIH · YALE UNIVERSITY · PI WILLIAM C BECKER, Alicia Heapy · 2017 to 2026
$16.4M
Complementary and Integrative Health for Pain in the VA: A National Demonstration ProjectIU1HX002607 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI TAYLOR, STEPHANIE L, ZELIADT, STEVEN BACCHUS · 2018 to 2025
–
HSRD VA IK6 HX003766HSRD VA IU1 HX002607NCATS NIH HHS UL1 TR001863NCCIH NIH HHS U24 AT009769
6 · The paper itself

Abstract

Pragmatic clinical trials (PCTs) are well-suited to address unmet healthcare needs, such as those arising from the dual public health crises of chronic pain and opioid misuse, recently exacerbated by the COVID-19 pandemic. These overlapping epidemics have complex, multifactorial etiologies, and PCTs can be used to investigate the effectiveness of integrated therapies that are currently available but underused. Yet individual pragmatic studies can be limited in their reach because of existing structural and cultural barriers to dissemination and implementation. The National Institutes of Health, Department of Defense, and Department of Veterans Affairs formed an interagency research partnership, the Pain Management Collaboratory. The partnership combines pragmatic trial design with collaborative tools and relationship building within a large network to advance the science and impact of nonpharmacological approaches and integrated models of care for the management of pain and common co-occurring conditions. The Pain Management Collaboratory team supports 11 large-scale, multisite PCTs in veteran and military health systems with a focus on team science with the shared aim that the "whole is greater than the sum of the parts." Herein, we describe this integrated approach and lessons learned, including incentivizing all parties; proactively offering frequent opportunities for problem-solving; engaging stakeholders during all stages of research; and navigating competing research priorities. We also articulate several specific strategies and their practical implications for advancing pain management in active clinical, "real-world," settings.

Indexed as

Military PersonnelPragmatic Clinical Trials as TopicVeteransCOVID-19HumansPain ManagementPandemicsResearch Design

Identifiers

PMID34791412
PMCPMC9389906
OpenAlexW3211888837

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.