ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2022
Relative Trajectories of Gait and Cognitive Decline in Aging.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Characterizing the supraspinal sensorimotor control of walking using MRI-compatible system: a systematic review.Journal of neuroengineering and rehabilitation · 2024Pooled it
- Identification and phenotypic profiling of subgroups with distinct cognitive aging trajectories.GeroScience · 2026Article
- Article
- A longitudinal resource for mapping interindividual variation in the aging connectome.Scientific data · 2026Article
- Multidimensional modeling of biological aging: integrating gait, eye movement, rest-state functional connectivity, and plasma biomarkers in non-dementia older adults.The journal of prevention of Alzheimer's disease · 2026Article
- Physical activity trajectories and cognitive decline among older adults in China: a longitudinal cohort study.BMC geriatrics · 2025Article
- Motoric cognitive risk syndrome: prevalence and associated sociodemographic and clinical factors in primary care settings in Brazil.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- An open, longitudinal resource for mapping interindividual variation in the aging connectome.medRxiv : the preprint server for health sciences · 2025Article
- Gray Matter Covariance Networks Associated With Parental Longevity-Results From the LonGenity Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Association between high plasma p-tau181 level and gait changes in patients with mild cognitive impairment.Scientific reports · 2025Article
- Neuroimaging Correlates of 3 Distinct Physical-Cognitive Phenotypes in Cognitively Normal Older Adults: The Gothenburg H70 Cohort Study.Neurology · 2025Article
- Aging disrupts locus coeruleus-driven norepinephrine transmission in the prefrontal cortex: Implications for cognitive and motor decline.Aging cell · 2025Article
- Hand dexterity and mobility independently predict cognition in older adults: a multi-domain regression analysis.Frontiers in aging neuroscience · 2025Article
- Modeling and validation of wearable sensor-based gait parameters in Parkinson's disease patients with cognitive impairment.Frontiers in aging neuroscience · 2025Article
- Temporal Sequence of Incident Mild Cognitive Impairment, Incident Parkinsonism, and Risk of Death in Unimpaired Community-Dwelling Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Cognitive reserve proxies are associated with age-related cognitive decline - Not age-related gait speed decline.Neurobiology of aging · 2024Article
- Adult Physical Function Has Roots in Early Childhood Brain Function: A Five-Decade Cohort Study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- Association Between Cognitive Trajectories and Subsequent Health Status, Depressive Symptoms, and Mortality Among Older Adults in the United States: Findings From a Nationally Representative Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Longitudinal Associations of Social Support and Gait Speed Decline in Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Longitudinal associations between the frequency of playing Mahjong and cognitive functioning among older people in China: evidence from CLHLS, 2008-2018.Frontiers in public health · 2024Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundGait and cognition decline with advancing age, and presage the onset of dementia. Yet, the relative trajectories of gait and cognitive decline in aging are poorly understood-particularly among those with the motoric cognitive risk (MCR) syndrome. This study compared changes in simple and complex gait performance and cognition, as a function of age and MCR.
methodsWe examined gait and cognitive functions of 1 095 LonGenity study participants (mean age = 75.4 ± 6.7 years) with up to 12 years of annual follow-up. Participants were of Ashkenazi Jewish descent, free of dementia, ambulatory, and had a 12.2% MCR prevalence at baseline. Gait speed was measured at usual pace walking (single-task walking, STW-speed) and walking while talking (WWT-speed). Eleven neuropsychological test scores were examined separately, and as a global cognition composite. Linear mixed-effects models adjusted for baseline sex, education, parental longevity, cognitive impairment, and global health were used to estimate changes in gait and cognition, as a function of age and MCR.
resultsSTW-speed, WWT-speed, and cognitive tests performance declined in a nonlinear (accelerating) fashion with age. STW-speed declined faster than WWT-speed and cognitive test scores. People with MCR showed faster rates of decline on figure copy and phonemic fluency.
conclusionsGait declines at a faster rate than cognition in aging. People with MCR are susceptible to faster decline in visuospatial, executive, and language functions. This study adds important knowledge of trajectories of gait and cognitive decline in aging, and identifies MCR as a risk factor for accelerated cognitive decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.