Evidence map›Paper›PMID 34790976›Full record

ArticleThe journal of cardiovascular aging2021

GSNOR regulates cardiomyocyte differentiation and maturation through protein S-nitrosylation.

Zachary W Grimmett, Nicholas M Venetos, Richard T Premont, Jonathan S Stamler

Open access · hybridAbstract read
In one paragraph

Article in The journal of cardiovascular aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Zachary W GrimmettDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Nicholas M VenetosInstitute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Richard T PremontInstitute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Jonathan S StamlerInstitute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Case Western Reserve University · USDiscovery Institute · USUniversity School · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
Regulation of Beta-Adrenergic Receptor Signaling by S-NitrosylationP01HL075443 · NHLBI · DUKE UNIVERSITY · PI STAMLER, JONATHAN S. · 2004 to 2019
$26.1M
Project 3 - Personalized cystic fibrosis treatment strategies with synergistic therapies Identified in vitro.P01HL128192 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI GASTON, BENJAMIN · 2016 to 2020
$12.2M
S-nitrosylation signaling in asthmaP01HL158507 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI LAHM, TIM · 2021 to 2025
$12.0M
Restoration and Function of S-Nitrosothiol in Stored BloodR01HL126900 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI JONATHAN S. STAMLER · 2016 to 2026
$5.0M
Novel Regulation of Renal Function by S-NitrosylationR01DK119506 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI JONATHAN S. STAMLER, Hualin Zhou · 2018 to 2026
$3.7M
CWRU- Cardiovascular Research Training ProgramT32HL134622 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI JAIN, MUKESH KUMAR, PROWELLER, AARON · 2017 to 2021
$1.9M
NHLBI NIH HHS P01 HL075443NHLBI NIH HHS P01 HL128192NHLBI NIH HHS P01 HL158507NHLBI NIH HHS R01 HL126900NHLBI NIH HHS T32 HL134622NIDDK NIH HHS R01 DK119506NIGMS NIH HHS T32 GM007250
6 · The paper itself

Abstract

S-nitrosoglutathione reductase (GSNOR) is a denitrosylase enzyme responsible for reverting protein S-nitrosylation (SNO). In this issue, Salerno

Identifiers

PMID34790976
PMCPMC8594876
OpenAlexW3205878483

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.