Evidence map›Paper›PMID 34790764›Full record

ArticleAnnals of translational medicine2021

Anti-inflammatory effects of artesunate on atherosclerosis via miR-16-5p and TXNIP regulation of the NLRP3 inflammasome.

Bo Li, Zheqi Zhang, Yili Fu

Open access · diamondAbstract read
In one paragraph

Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

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  2. [Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Bo LiSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Zheqi ZhangDepartment of Endocrinology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Yili FuSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Fourth Affiliated Hospital of Harbin Medical University · CNHarbin Medical University · CNState Key Laboratory of Robotics and Systems

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAtherosclerosis (AS) is chronic inflammatory arterial disorder. Artesunate could exhibit anti-inflammatory activity in AS, but its role in AS is still in its incipient stage. In this study, we explored the anti-inflammatory effect of artesunate in AS and its underlying mechanism.

methodsWe isolated CD14

resultsDownregulated miR-16-5p and upregulated thioredoxin-interacting protein (TXNIP) was determined in CD14

conclusionsIn summary, the present study unveiled a mechanism underlying the anti-inflammatory role of artesunate in AS.

Indexed as

Artesunateatherosclerosis (AS)inflammasomeLR family pyrin domain containing 3 (NLRP3)microRNA-16-5p

Identifiers

PMID34790764
PMCPMC8576697
OpenAlexW3210332969

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.