Protective Effect of Hyperbaric Oxygen Treatment on Axon Degeneration after Acute Motor Axonal Neuropathy.

Ni Komang Sri Dewi Untari, Kurnia Kusumastuti, Guritno Suryokusumo, I Ketut Sudiana

Open access · goldAbstract read

In one paragraph

Article in Autoimmune diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.2field-weighted citation impact, top 42% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

Hyperbaric oxygen therapy improves recovery at acute motor axonal neuropathy case.Journal of neurosciences in rural practice
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ni Komang Sri Dewi UntariDepartment of Hyperbaric, Drs. Med. Rijadi S. Phys. Naval Health Institute, Surabaya, Indonesia.ORCID https://orcid.org/0000-0003-4179-5498

Kurnia KusumastutiDepartment of Neurology, Faculty of Medicine, Airlangga University, Surabaya, Indonesia.ORCID https://orcid.org/0000-0001-9904-6866

Guritno SuryokusumoDepartment of Hyperbaric, Faculty of Medicine, Pembangunan Nasional University, Jakarta, Indonesia.ORCID https://orcid.org/0000-0002-8546-7341

I Ketut SudianaDepartment of Pathology Anatomy, Faculty of Medicine, Airlangga University, Surabaya, Indonesia.ORCID https://orcid.org/0000-0003-0652-9362

Airlangga University · IDNasional University · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesAcute motor axonal neuropathy (AMAN) is a disease that leads to acute flaccid paralysis and may result from the binding of antibody and antigen to the spinal cord. The objective of this study is to evaluate the protective effect of hyperbaric oxygen treatment (HBOT) on axon degeneration of the spinal cord and sciatic nerve of the AMAN model rabbit. Axonal degeneration was assessed by evaluating glutathione (GSH) activity, interleukin-1

methodsTwenty-one New Zealand rabbits were divided into three groups. The treatment group was exposed to 100% oxygen at 2.4 ATA 90 minutes for 10 days at a decompression rate of 2.9 pounds per square inch/minute. GSH level was evaluated using an enzyme-linked immune-sorbent assay. An expression of IL-1

resultsRabbits exposed to HBO had high GSH activity levels (

conclusionsThese findings indicate that HBO therapy can decrease axon degeneration by triggering GSH activity, increasing IL-1

Identifiers

PMID34790416

DOI10.1155/2021/6627779

PMCPMC8592739

OpenAlexW3212865958

What OpenQuestion holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.