Evidence map›Paper›PMID 34790373›Full record

ArticleJournal of gastrointestinal oncology2021

Clinical application of nano-carbon to improve the accuracy of lymph node staging in patients with advanced gastric cancer receiving neoadjuvant chemotherapy: a prospective randomized controlled trial.

Peigang Yang, Yuan Tian, Bibo Tan, Pingan Ding, Honghai Guo, Yang Liu, Zhidong Zhang, Yong Li, Qun Zhao

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastrointestinal oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Efficacy of Nano-Carbon Tracing Versus Indocyanine Green in Lymph Node Detection for Minimally Invasive Colorectal Resection.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Peigang YangDepartment of Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Yuan TianDepartment of Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Bibo TanDepartment of Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Pingan DingDepartment of Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Honghai GuoDepartment of Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Yang LiuDepartment of Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Zhidong ZhangDepartment of Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Yong LiDepartment of Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Qun ZhaoDepartment of Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Fourth Hospital of Hebei Medical University · CNHebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe significance of nano-carbon for lymph node staging in radical gastrectomy for gastric cancer (GC) has been confirmed, but studies on its application for GC patients treated with neoadjuvant chemotherapy (NCT) are rare. The purpose of this study was to explore the clinical value of using carbon nanoparticles suspension injections (CNS) to improve the accuracy of lymph node staging (N staging) of NCT for advanced GC.

methods160 advanced GC patients receiving preoperative NCT were enrolled, according to the random number generated by computer, the enrolled patients were randomly divided into two groups: experimental group (n=80) and control group (n=80). The experimental group received endoscopic injection of CNS within 24 hours prior to NCT, while the control group received this within 24 hours post NCT and before D2 radical resection. SOX [oxaliplatin: 130 mg/(body surface area, BSA): m

resultsA total of 3,197 lymph nodes were harvested in the experimental group, including 384 metastatic lymph nodes, 1,424 stained lymph nodes, and 210 metastatic stained lymph nodes. The total number of lymph nodes harvested in the control group was 2,565, including 244 metastatic lymph nodes, 796 stained lymph nodes, and 94 metastatic stained lymph nodes. Compared with the control group, a higher rate of stained lymph nodes, a higher total number of lymph nodes, and an increased number of metastatic lymph nodes were detected in the experimental group.

conclusionsThe application of CNS before NCT in patients with advanced GC can minimize lymph node staging bias after NCT and improve its accuracy.

trial registrationChinese Clinical Trial Registry ChiCTR2100047407.

Indexed as

advanced gastric cancer (advanced GC)Carbon nanoparticleslymph node staging (N staging)neoadjuvant chemotherapy (NCT)

Identifiers

PMID34790373
PMCPMC8576249
OpenAlexW3206842423

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.