Coupling feature extraction method of resting state EEG Signals from amnestic mild cognitive impairment with type 2 diabetes mellitus based on weight permutation conditional mutual information.

This study aimed to find a good coupling feature extraction method to effectively analyze resting state EEG signals (rsEEG) of amnestic mild cognitive impairment(aMCI) with type 2 diabetes mellitus(T2DM) and normal control (NC) with T2DM. A method of EEG signal coupling feature extraction based on weight permutation conditional mutual information (WPCMI) was proposed in this research. With the WPCMI method, coupling feature strength of two time series in Alpha1, Alpha2, Beta1, Beta2 and Gamma bands for aMCI with T2DM and NC with T2DM could be extracted respectively. Then selected three frequency bands coupling feature matrix with the help of multi-spectral image transformation method to map it as spectral image characteristics. And finally classified these characteristics through the convolution neural network method(CNN). For aMCI with T2DM and NC with T2DM, the highest classification accuracy of 96%, 95%, 95% could be achieved respectively in the combination of three frequency bands (Alpha1, Alpha2, Gamma), (Beta1, Beta2 and Gamma) and (Alpha2, Beta1, Beta2). This WPCMI method highlighted the coupling dynamic characteristics of EEG signals, and its classification performance was better than all previous methods in aMCI with T2DM diagnosis field. WPCMI method could be used as an effective biomarker to distinguish EEG signals of aMCI with T2DM and NC with T2DM. The coupling feature extraction method used in this paper provided a new perspective for the EEG analysis of aMCI with T2DM.