Evidence map›Paper›PMID 34790251›Full record

ArticleComputational and mathematical methods in medicine2021

Porcine-Stimulated Human Tr1 Cells Showed Enhanced Suppression in Xenoantigen Stimulation Response.

Xiaoting Chen, Hongwen Ma, Lina Gong, Guang Yang, Xi Jin

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and mathematical methods in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xiaoting ChenDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0002-2929-2110
Hongwen MaDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Lina GongDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Guang YangAnimal Experimental Center, West China Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0002-7207-854X
Xi JinDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0003-3700-3339
Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 1 regulatory T (Tr1) cells play a fundamental role in maintaining and inducing immune tolerance. Our preliminary study demonstrated that an interleukin- (IL-) 10-mediated pathway is a possible regulatory mechanism underlying the xenoantigen-specific human Treg enhanced suppressive capacity. Here, we developed a feasible protocol for expanding IL-10-induced xenoantigen-specific human Tr1 cells in vitro which would be more efficient in transplantation immunotherapy efficiency. In this study, xenoantigen-specific Tr1 cells are generated from human naive CD4

Indexed as

Immune ToleranceAdoptive TransferAdultAnimalsAntigens, HeterophileApyraseCell ProliferationCoculture TechniquesComputational BiologyFemaleHumansInterleukin-10Interleukin-5In Vitro TechniquesLymphocyte ActivationMaleAntigens, HeterophileApyraseENTPD1 protein, humanIL10 protein, humanIL5 protein, humanInterleukin-10Interleukin-5

Identifiers

PMID34790251
PMCPMC8592757
OpenAlexW3211429067

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.