Evidence map›Paper›PMID 34790205›Full record

ReviewFrontiers in immunology2021

Role of Toll-Like Receptors in Neuroimmune Diseases: Therapeutic Targets and Problems.

Haixia Li, Shan Liu, Jinming Han, Shengxian Li, Xiaoyan Gao, Meng Wang, Jie Zhu, Tao Jin

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Palmitic Acid Amplifies Microglial Inflammatory Activation Involving C5aR1-Sensitive Inflammatory Signaling and JMJD3/H3K27me3-Related Epigenetic Changes.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Haixia LiDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China.
Shan LiuDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China.
Jinming HanDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Shengxian LiDepartment of Urology, The First Hospital of Jilin University, Changchun, China.
Xiaoyan GaoDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China.
Meng WangDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China.
Jie ZhuDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China.
Tao JinDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Toll-like receptors (TLRs) are a class of proteins playing a key role in innate and adaptive immune responses. TLRs are involved in the development and progression of neuroimmune diseases

Indexed as

Disease SusceptibilityAnimalsBiomarkersDiagnosis, DifferentialDisease ManagementDrug DevelopmentGene Expression RegulationHumansImmune System DiseasesMolecular Targeted TherapyMultigene FamilyNervous System DiseasesOrgan SpecificitySignal TransductionStructure-Activity RelationshipTheranostic NanomedicineBiomarkersToll-Like ReceptorsGuillain-Barré syndromeinhibitorsmultiple sclerosisMyasthenia gravisneuroimmune diseasesneuromyelitis optica spectrum disordertoll-like receptors

Identifiers

PMID34790205
PMCPMC8591135

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.