ArticleFrontiers in neuroscience2021
Temporary Unilateral Hearing Loss Impairs Spatial Auditory Information Processing in Neurons in the Central Auditory System.
Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Developmental auditory deprivation in one ear impairs brainstem binaural processing and reduces spatial hearing acuity.PLoS biology · 2025Article
- Population coding of auditory space in the dorsal inferior colliculus persists with altered binaural cues.bioRxiv : the preprint server for biology · 2024Article
- Binaural hearing in monaural conductive or mixed hearing loss fitted with unilateral Bonebridge.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2024Article
- Experience-Dependent Plasticity in Nucleus Laminaris of the Barn Owl.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Auditory Deprivation during Development Alters Efferent Neural Feedback and Perception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Benefits of bone conduction hearing aid in children with unilateral aural atresia.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2023Article
- Persistence and generalization of adaptive changes in auditory localization behavior following unilateral conductive hearing loss.Frontiers in neuroscience · 2023Article
- Review of Binaural Processing With Asymmetrical Hearing Outcomes in Patients With Bilateral Cochlear Implants.Trends in hearingReview
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Temporary conductive hearing loss (CHL) can lead to hearing impairments that persist beyond resolution of the CHL. In particular, unilateral CHL leads to deficits in auditory skills that rely on binaural input (e.g., spatial hearing). Here, we asked whether single neurons in the auditory midbrain, which integrate acoustic inputs from the two ears, are altered by a temporary CHL. We introduced 6 weeks of unilateral CHL to young adult chinchillas via foam earplug. Following CHL removal and restoration of peripheral input, single-unit recordings from inferior colliculus (ICC) neurons revealed the CHL decreased the efficacy of inhibitory input to the ICC contralateral to the earplug and increased inhibitory input ipsilateral to the earplug, effectively creating a higher proportion of monaural responsive neurons than binaural. Moreover, this resulted in a ∼10 dB shift in the coding of a binaural sound location cue (interaural-level difference, ILD) in ICC neurons relative to controls. The direction of the shift was consistent with a compensation of the altered ILDs due to the CHL. ICC neuron responses carried ∼37% less information about ILDs after CHL than control neurons. Cochlear peripheral-evoked responses confirmed that the CHL did not induce damage to the auditory periphery. We find that a temporary CHL altered auditory midbrain neurons by shifting binaural responses to ILD acoustic cues, suggesting a compensatory form of plasticity occurring by at least the level of the auditory midbrain, the ICC.
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