ArticleNature2021
Cell-type specialization is encoded by specific chromatin topologies.
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Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers.
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140citing papers in PubMed
16.7field-weighted citation impact, top 1% of its field
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Who cites it
140 citing papers in PubMed, 226 citations in OpenAlex.
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- ssJSD: A Fusion of Sparsity and Spatial Information for HiC Single-Cell Clustering.bioRxiv : the preprint server for biology · 2026Article
- A scaffolding element rewires local 3D chromatin architecture during differentiation.Nature communications · 2026Article
- Mega-enhancers compartmentalize transcriptionally active long genes in the brain.Nature cell biology · 2026Article
- Article
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- Sequential-GAM constructs the single-cell geometric 3D genome structure.Nucleic acids research · 2026Article
- Evolution of CTCF binding sites in the human genome.Molecular biology and evolution · 2026Article
- OptoLoop - an optogenetic tool to probe the functional role of genome organization.Journal of cell science · 2026Article
- RNAPII and DNA supercoiling regulate cohesin engagement in neurons.Nucleic acids research · 2026Article
- Chromatin-associated intronic RNAs from long genes form introsomes that shape nuclear architecture in neuronal cells.bioRxiv : the preprint server for biology · 2026Article
- SIRT6 overexpression counteracts chromatin aging in the male murine liver.Nature communications · 2026Article
- Highly efficient chromatin conformation capture with post-enrichment in single cells by HiChew.Genome biology · 2026Article
- The 3D genomics of lampbrush chromosomes highlights the role of active transcription in chromatin organization.Nucleic acids research · 2026Article
- Histo-LCM-Hi-C Reveals 3D Chromatin Conformations of Spatially Localized Rare Cells in Tissues at High Resolution.Genomics, proteomics & bioinformatics · 2026Article
- How human-derived brain organoids are built differently from brain organoids derived from genetically-close relatives: a multi-scale hypothesis.Soft matter · 2026Article
- Mechanoepigenetics in musculoskeletal disease.Osteoarthritis and cartilage · 2026Review
- Recurrence plot reconstruction reveals chromosomal reorganization before territory formation.NAR genomics and bioinformatics · 2026Article
- Single-Cell Atlas of Transcription and Chromatin States Reveals Regulatory Programs in the Human Brain.bioRxiv : the preprint server for biology · 2026Article
80 more citing papers are in PubMed but not listed here.
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Authors and funding
32 authors at 11 institutions in 9 countries.
Warren Winick-Ng *Max-Delbrück Centre for Molecular Medicine, Berlin Institute for Medical Systems Biology, Epigenetic Regulation and Chromatin Architecture Group, Berlin, Germany. warren.winick-ng@mdc-berlin.de.ORCID http://orcid.org/0000-0002-8716-5558
Alexander Kukalev *Max-Delbrück Centre for Molecular Medicine, Berlin Institute for Medical Systems Biology, Epigenetic Regulation and Chromatin Architecture Group, Berlin, Germany.
Izabela Harabula *Max-Delbrück Centre for Molecular Medicine, Berlin Institute for Medical Systems Biology, Epigenetic Regulation and Chromatin Architecture Group, Berlin, Germany.
Luna Zea-Redondo *Max-Delbrück Centre for Molecular Medicine, Berlin Institute for Medical Systems Biology, Epigenetic Regulation and Chromatin Architecture Group, Berlin, Germany.
Dominik Szabó *Max-Delbrück Centre for Molecular Medicine, Berlin Institute for Medical Systems Biology, Epigenetic Regulation and Chromatin Architecture Group, Berlin, Germany.
Mandy MeijerLaboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-3314-1224
Leonid SerebreniMax-Delbrück Centre for Molecular Medicine, Berlin Institute for Medical Systems Biology, Epigenetic Regulation and Chromatin Architecture Group, Berlin, Germany.
Yingnan ZhangSchool of Electrical Engineering and Computer Science, Ohio University, Athens, OH, USA.
Simona BiancoDipartimentio di Fisica, Università di Napoli Federico II, and INFN Napoli, Complesso Universitario di Monte Sant'Angelo, Naples, Italy.ORCID http://orcid.org/0000-0001-5819-060X
Andrea M ChiarielloDipartimentio di Fisica, Università di Napoli Federico II, and INFN Napoli, Complesso Universitario di Monte Sant'Angelo, Naples, Italy.ORCID http://orcid.org/0000-0002-6112-0167
Ibai Irastorza-AzcarateMax-Delbrück Centre for Molecular Medicine, Berlin Institute for Medical Systems Biology, Epigenetic Regulation and Chromatin Architecture Group, Berlin, Germany.
Christoph J ThiemeMax-Delbrück Centre for Molecular Medicine, Berlin Institute for Medical Systems Biology, Epigenetic Regulation and Chromatin Architecture Group, Berlin, Germany.ORCID http://orcid.org/0000-0002-1566-0971
Thomas M SparksMax-Delbrück Centre for Molecular Medicine, Berlin Institute for Medical Systems Biology, Epigenetic Regulation and Chromatin Architecture Group, Berlin, Germany.
Sílvia CarvalhoMax-Delbrück Centre for Molecular Medicine, Berlin Institute for Medical Systems Biology, Epigenetic Regulation and Chromatin Architecture Group, Berlin, Germany.
Luca FiorilloDipartimentio di Fisica, Università di Napoli Federico II, and INFN Napoli, Complesso Universitario di Monte Sant'Angelo, Naples, Italy.ORCID http://orcid.org/0000-0003-2967-0123
Francesco MusellaDipartimentio di Fisica, Università di Napoli Federico II, and INFN Napoli, Complesso Universitario di Monte Sant'Angelo, Naples, Italy.
Ehsan IraniMax-Delbrück Centre for Molecular Medicine, Berlin Institute for Medical Systems Biology, Epigenetic Regulation and Chromatin Architecture Group, Berlin, Germany.
Elena Torlai TrigliaMax-Delbrück Centre for Molecular Medicine, Berlin Institute for Medical Systems Biology, Epigenetic Regulation and Chromatin Architecture Group, Berlin, Germany.ORCID http://orcid.org/0000-0002-6059-0116
Aleksandra A KolodziejczykCavendish Laboratory, University of Cambridge, Cambridge, UK.
Andreas AbentungInstitute for Neuroscience, Medical University of Innsbruck, Innsbruck, Austria.
Galina ApostolovaInstitute for Neuroscience, Medical University of Innsbruck, Innsbruck, Austria.
Eleanor J PaulInstitute of Clinical Sciences, Imperial College London, London, UK.ORCID http://orcid.org/0000-0003-1183-9285
Vedran FrankeMax-Delbrück Centre for Molecular Medicine, Berlin Institute for Medical Systems Biology, Bioinformatics and Omics Data Science Platform, Berlin, Germany.ORCID http://orcid.org/0000-0003-3606-6792
Rieke KempferMax-Delbrück Centre for Molecular Medicine, Berlin Institute for Medical Systems Biology, Epigenetic Regulation and Chromatin Architecture Group, Berlin, Germany.
Altuna AkalinMax-Delbrück Centre for Molecular Medicine, Berlin Institute for Medical Systems Biology, Bioinformatics and Omics Data Science Platform, Berlin, Germany.ORCID http://orcid.org/0000-0002-0468-0117
Sarah A TeichmannCavendish Laboratory, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-6294-6366
Georg DechantInstitute for Neuroscience, Medical University of Innsbruck, Innsbruck, Austria.
Mark A UnglessInstitute of Clinical Sciences, Imperial College London, London, UK.
Mario NicodemiDipartimentio di Fisica, Università di Napoli Federico II, and INFN Napoli, Complesso Universitario di Monte Sant'Angelo, Naples, Italy.
Lonnie WelchSchool of Electrical Engineering and Computer Science, Ohio University, Athens, OH, USA.
Gonçalo Castelo-BrancoLaboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-2247-9393
Ana PomboMax-Delbrück Centre for Molecular Medicine, Berlin Institute for Medical Systems Biology, Epigenetic Regulation and Chromatin Architecture Group, Berlin, Germany. ana.pombo@mdc-berlin.de.ORCID http://orcid.org/0000-0002-7493-6288
Max Delbrück Center · DEIstituto Nazionale di Fisica Nucleare, Sezione di Napoli · ITInnsbruck Medical University · ATKarolinska Institutet · SEOhio University · USUniversity of Cambridge · GBBroad Institute · USImperial College London · GBKing's College London · GBResearch Institute of Molecular Pathology · ATUniversidade do Porto · PT
Funding
San Diego Center for 4D Nucleome ResearchU54DK107977 · NIDDK · LUDWIG INSTITUTE FOR CANCER RES LTD · PI REN, BING · 2015 to 2019
$9.4MCenter for Integrated Multi-modal and Multi-scale Nucleome ResearchUM1HG011585 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DULAC, CATHERINE, LEIN, ED · 2020 to 2024
$6.7MMedical Research Council MC_U120085816NHGRI NIH HHS UM1 HG011585NIDDK NIH HHS U54 DK107977
Abstract
The three-dimensional (3D) structure of chromatin is intrinsically associated with gene regulation and cell function
Indexed as
Chromatin Assembly and DisassemblyGenesMolecular ConformationAnimalsBinding SitesBrainCellsChromatinGene Expression RegulationMaleMiceMultigene FamilyNeuronsNucleic Acid DenaturationTranscription FactorsChromatinTranscription Factors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.