ArticleNature2021
Structural insights into Ubr1-mediated N-degron polyubiquitination.
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Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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66citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
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Who cites it
66 citing papers in PubMed, 130 citations in OpenAlex.
- Molecular insights into NLRP1 Gly/N-degron recognition by CRL2Acta crystallographica. Section F, Structural biology communications · 2026Article
- Steric Gating Contributes to the Preferential Ubiquitin Charging of BIRC6 by UBA6 versus UBA1.Nature communications · 2026Article
- A machine learning model predicts protein stability of annotated and alternate protein isoforms.bioRxiv : the preprint server for biology · 2026Article
- Article
- Allosteric activation of RNF20/RNF40-RAD6A-mediated H2BK120 monoubiquitylation by H2BS112 GlcNAcylation.Nature chemical biology · 2026Article
- A C-degron regulates Chk1 kinase by allowing stability of inactive Chk1 and by making it short- lived upon activation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- From Covalent Traps to Fluorescent Beacons: The Expanding Arsenal of Chemical Probes for Studying Ubiquitin and Ubiquitin-Like Proteins.Angewandte Chemie (International ed. in English) · 2026Review
- Structural basis for E4 enzyme Ufd2-catalyzed K48/K29 branched ubiquitin chains.Nature chemical biology · 2026Article
- MIRAGE: A Bayesian statistical method for gene-level rare-variant analysis incorporating functional annotations.American journal of human genetics · 2026Article
- E2 variants for probing E3 ubiquitin ligase activities.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Design and Semisynthesis of Ubiquitin Extension Probes.Methods in molecular biology (Clifton, N.J.) · 2026Article
- A UBH-UBX module amplifies p97/VCP's unfolding power to facilitate protein extraction and degradation.Nature communications · 2025Article
- Contribution of UbrA, a ubiquitin ligase essential for Arg/N-degron pathway, to peptidase gene expression inApplied and environmental microbiology · 2025Article
- TRIP12 structures reveal HECT E3 formation of K29 linkages and branched ubiquitin chains.Nature structural & molecular biology · 2025Article
- Advances in the chemical synthesis of human proteoforms.Science China. Life sciences · 2025Review
- Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control.Science (New York, N.Y.) · 2025Article
- Structural basis for the recognition and ubiquitylation of type-2 N-degron substrate by PRT1 plant N-recognin.Nature communications · 2025Article
- An alternative pocket for binding the N-degrons by the UBR1 and UBR2 ubiquitin E3 ligases.Protein science : a publication of the Protein Society · 2025Article
- UBR-1 enzyme network regulates glutamate homeostasis to affect organismal behavior and developmental viability.bioRxiv : the preprint server for biology · 2025Article
- Mechanism of nascent chain removal by the ribosome-associated quality control complex.Nature communications · 2025Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 2 countries.
Man Pan *Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA. panman@sjtu.edu.cn.ORCID http://orcid.org/0000-0001-7216-8193
Qingyun Zheng *Tsinghua-Peking Center for Life Sciences, Department of Chemistry, Tsinghua University, Beijing, China.
Tian Wang *Tsinghua-Peking Center for Life Sciences, Department of Chemistry, Tsinghua University, Beijing, China.
Lujun Liang *Tsinghua-Peking Center for Life Sciences, Department of Chemistry, Tsinghua University, Beijing, China.
Junxiong MaoTsinghua-Peking Center for Life Sciences, Department of Chemistry, Tsinghua University, Beijing, China.
Chong ZuoTsinghua-Peking Center for Life Sciences, Department of Chemistry, Tsinghua University, Beijing, China.
Ruichao DingTsinghua-Peking Center for Life Sciences, Department of Chemistry, Tsinghua University, Beijing, China.
Huasong AiTsinghua-Peking Center for Life Sciences, Department of Chemistry, Tsinghua University, Beijing, China.
Yuan XieDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-5105-7136
Dong SiDivision of Computing and Software Systems, University of Washington Bothell, Bothell, WA, USA.ORCID http://orcid.org/0000-0001-7039-2589
Yuanyuan YuDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA. yuyy@shu.edu.cn.ORCID http://orcid.org/0000-0002-5379-5148
Lei LiuTsinghua-Peking Center for Life Sciences, Department of Chemistry, Tsinghua University, Beijing, China. lliu@mail.tsinghua.edu.cn.ORCID http://orcid.org/0000-0001-6290-8602
Minglei ZhaoDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA. mlzhao@uchicago.edu.ORCID http://orcid.org/0000-0001-5832-6060
Center for Life Sciences · CNShanghai University · CNUniversity of Chicago · USKing Center · USUniversity of Illinois Chicago · USUniversity of Washington Bothell · US
Funding
ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2MStructural and Functional Studies of Molecular Machines Involved in Chemical Modifications of MacromoleculesR35GM143052 · NIGMS · UNIVERSITY OF CHICAGO · PI ZHAO, MINGLEI · 2021 to 2025
$2.1MNIGMS NIH HHS R01 GM129325NIGMS NIH HHS R35 GM143052
Abstract
The N-degron pathway targets proteins that bear a destabilizing residue at the N terminus for proteasome-dependent degradation
Indexed as
UbiquitinationBinding SitesBiocatalysisCryoelectron MicroscopyLysineModels, MolecularProteasome Endopeptidase ComplexProteolysisReproducibility of ResultsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsUbiquitinUbiquitin-Conjugating EnzymesUbiquitin-Protein LigasesLysineProteasome Endopeptidase ComplexRAD6 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsUbiquitinUbiquitin-Conjugating EnzymesUbiquitin-Protein LigasesUBR1 protein, S cerevisiae
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.