Evidence map›Paper›PMID 34789876›Full record

ArticleNature2021

Single-cell transcriptomic characterization of a gastrulating human embryo.

Richard C V Tyser, Elmir Mahammadov, Shota Nakanoh, Ludovic Vallier, Antonio Scialdone, Shankar Srinivas

Open access · greenAbstract read
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 250 papers.

0numbers the graph read from it
0cells of the map it votes in
250citing papers in PubMed
26.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

250 citing papers in PubMed, 446 citations in OpenAlex.

  1. Article
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  9. Article
  10. Review
  11. Macrophages in embryonic development.Nature reviews. Immunology · 2026
    Review
  12. Article
  13. Article
  14. Review
  15. Animals : an open access journal from MDPI · 2026
    Article
  16. Computational modelling of cell identity.The Biochemical journal · 2026
    Review
  17. Review
  18. Article
  19. Review
  20. Review

190 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Richard C V Tyser *Department of Physiology, Anatomy and Genetics, South Parks Road, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-7884-1756
Elmir Mahammadov *Institute of Epigenetics and Stem Cells, Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany.ORCID http://orcid.org/0000-0003-0008-1413
Shota NakanohWellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge, UK.
Ludovic VallierWellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge, UK.ORCID http://orcid.org/0000-0002-3848-2602
Antonio ScialdoneInstitute of Epigenetics and Stem Cells, Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany. antonio.scialdone@helmholtz-muenchen.de.ORCID http://orcid.org/0000-0002-4956-2843
Shankar Srinivas *Department of Physiology, Anatomy and Genetics, South Parks Road, University of Oxford, Oxford, UK. shankar.srinivas@dpag.ox.ac.uk.ORCID http://orcid.org/0000-0001-5726-7791
Helmholtz Zentrum München · DEUniversity of Oxford · GBWellcome/MRC Cambridge Stem Cell Institute · GB

Funding

British Heart Foundation FS/18/24/33424European Research CouncilMedical Research Council MC_PC_17230Medical Research Council MR/R006237/1Wellcome Trust 099175Wellcome Trust 099175/Z/12/ZWellcome Trust 103788Wellcome Trust 103788/Z/14/ZWellcome Trust 105031Wellcome Trust 105031/C/14/ZWellcome Trust 108438Wellcome Trust 108438/Z/15/ZWellcome Trust 215116Wellcome Trust 215116/Z/18/ZWellcome Trust MR/R006237/1
6 · The paper itself

Abstract

Gastrulation is the fundamental process in all multicellular animals through which the basic body plan is first laid down

Indexed as

Gene Expression ProfilingSingle-Cell AnalysisTranscriptomeAnimalsCell DifferentiationDatasets as TopicEmbryo, MammalianEndodermErythrocytesFemaleGastrulaGastrulationGerm CellsHumansMaleMesoderm

Identifiers

PMID34789876
PMCPMC7615353
OpenAlexW3213709307

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.