ArticleScientific reports2021
Polystyrene nanoplastics and microplastics can act as Trojan horse carriers of benzo(a)pyrene to mussel hemocytes in vitro.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 96 citations in OpenAlex.
- The effects of microplastics and nanoplastics on cardiovascular disease: mechanisms and perspectives.Nature reviews. Cardiology · 2026Review
- Distribution and Effects of Model Palladium-Doped Nanoplastics in the Marine MusselNanomaterials (Basel, Switzerland) · 2026Article
- Transcriptomic evidence suggesting a Trojan horse-like synergistic effect in exposures to nanoplastics and benzo[a]pyrene on a yellowfin sea bream muscle derived cell line.Journal of fish biology · 2026Article
- Article
- Renal Accumulation and Hemocyte-Mediated Internalization After Acute Exposure to Injected Polyethylene Terephthalate Nanoplastics (PET-NPs) in the Freshwater GastropodJournal of xenobiotics · 2026Article
- Review
- The Parkinson's pandemic: prioritizing environmental policy and biological resilience via the gut.The Journal of clinical investigation · 2026Article
- Coexposure of Micro and Nano-Plastics with Pesticides: Cytotoxicity and Bioaccumulation Effects on a Fish Intestinal Cell Line.Environmental science & technology · 2026Article
- From Chromosomal Aberrations to Transcriptome Analysis: Four Decades of Research in Bivalve Genotoxicity.International journal of molecular sciences · 2025Review
- Comparative Toxicity of Micro, Nano, and Leachate Fractions of Three Rubber Materials to Freshwater Species: Zebrafish andMicroplastics (Basel, Switzerland) · 2025Article
- Activation of gut metabolite ACSL4/LPCAT3 by microplastics in drinking water mediates ferroptosis via gut-kidney axis.Communications biology · 2025Article
- Review
- In Vitro and In Vivo Genotoxicity of Polystyrene Microplastics: Evaluation of a Possible Synergistic Action with Bisphenol A.Journal of xenobiotics · 2024Article
- Assessment of the In Vitro Phosphatidylinositol Glycan Class A (PIG-A) Gene Mutation Assay Using Human TK6 and Mouse Hepa1c1c7 Cell Lines.Journal of xenobiotics · 2024Article
- Polystyrene nanoplastic exposure actives ferroptosis by oxidative stress-induced lipid peroxidation in porcine oocytes during maturation.Journal of animal science and biotechnology · 2024Article
- The impact of nanomaterials on autophagy across health and disease conditions.Cellular and molecular life sciences : CMLS · 2024Review
- Nanoplastics increaseArhiv za higijenu rada i toksikologiju · 2024Article
- Human Exposure to Microplastics and Its Associated Health Risks.Environment & health (Washington, D.C.) · 2023Review
- Validated method for polystyrene nanoplastic separation in aqueous matrices by asymmetric-flow field flow fraction coupled to MALS and UV-Vis detectors.Mikrochimica acta · 2023Article
- Machine Learning to Predict the Adsorption Capacity of Microplastics.Nanomaterials (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In this work we studied the ability of polystyrene (PS) nanoplastics (NPs) and microplastics (MPs) to transfer benzo(a)pyrene (BaP) to mussel hemocytes and to produce toxic effects in vitro. For this, intracellular fate and toxicity of PS NPs (0.05 μm) and MPs (0.5 and 4.5 μm) alone or with BaP and of BaP alone were assessed. Particles of 0.05 and 0.5 µm largely aggregated in the exposure medium whereas presence of BaP reduced particle aggregation. Cells internalized PS NPs and MPs alone or with BaP and these were found inside and outside lysosomes, depending on their size. PS particles alone or with BaP were cytotoxic to hemocytes only at the highest concentrations tested. The same was true for most sublethal endpoints except for increased phagocytic activity provoked by NPs and 0.5 μm MPs at lower concentrations. Plastic particles appeared to be the main drivers for reduced plasma membrane integrity and increased phagocytic and lysosomal activities whereas BaP appeared to contribute more to reduced cell viability and phagocytosis and increased ROS production and genotoxicity. Overall, PS NPs and MPs can act as carriers of BaP to mussel hemocytes, rising concerns about risks plastics associated to pollutants may pose to aquatic organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.