Evidence map›Paper›PMID 34789831›Full record

ArticleScientific reports2021

Neural correlates of vocal initiation in the VTA/SNc of juvenile male zebra finches.

Shin Yanagihara, Maki Ikebuchi, Chihiro Mori, Ryosuke O Tachibana, Kazuo Okanoya

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Striatal Dopamine at Learned Sequence Boundaries Sustains Birdsong.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Shin YanagiharaGraduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan. yanagihara001@gmail.com.
Maki IkebuchiRIKEN Center for Brain Science, Saitama, Japan.
Chihiro MoriDepartment of Molecular Biology, Faculty of Pharmaceutical Sciences, Teikyo University, Tokyo, Japan.
Ryosuke O TachibanaGraduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.
Kazuo OkanoyaGraduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.
The University of Tokyo · JPRIKEN Center for Brain Science · JPTeikyo University · JPTokyo University of the Arts · JP

Funding

MEXT/JSPS KAKENHI 17H06380 (#4903)MEXT/JSPS KAKENHI 17K07066
6 · The paper itself

Abstract

Initiation and execution of complex learned vocalizations such as human speech and birdsong depend on multiple brain circuits. In songbirds, neurons in the motor cortices and basal ganglia circuitry exhibit preparatory activity before initiation of song, and that activity is thought to play an important role in successful song performance. However, it remains unknown where a start signal for song is represented in the brain and how such a signal would lead to appropriate vocal initiation. To test whether neurons in the midbrain ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) show activity related to song initiation, we carried out extracellular recordings of VTA/SNc single units in singing juvenile male zebra finches. We found that a subset of VTA/SNc units exhibit phasic activity precisely time-locked to the onset of the song bout, and that the activity occurred specifically at the beginning of song. These findings suggest that phasic activity in the VTA/SNc represents a start signal that triggers song vocalization.

Indexed as

Vocalization, AnimalAnimalsBehavior, AnimalElectrophysiological PhenomenaFinchesFluorescent Antibody TechniqueLearningMaleNeuronsPars CompactaVentral Tegmental Area

Identifiers

PMID34789831
PMCPMC8599707
OpenAlexW3214047277

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.