Observational studyScientific reports2021
Biphasic (5-2%) oxygen concentration strategy significantly improves the usable blastocyst and cumulative live birth rates in in vitro fertilization.
Observational study in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07050537 (A Multicenter Prospective Randomized Controlled Clinical Trial Comparing Constant), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multicenter Prospective Randomized Controlled Clinical Trial Comparing Constant (5%) Versus Sequential (5%-2%) Oxygen Concentration Embryo Culture Protocols in Assisted Reproductive Technology: Evaluating Term Live Birth and Offspring Health Outcomes
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Congenital anomaly and perinatal outcome following blastocyst- vs cleavage-stage embryo transfer: systematic review and network meta-analysis.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2023Pooled it
- Ultra-low oxygen tension duringbioRxiv : the preprint server for biology · 2026Article
- Impacts of Oxygen Tension on Developmental Competence of Preimplantation Embryos.Biomolecules · 2026Review
- Ecologically relevant low oxygen levels reduce unfertilized oocyte output inmicroPublication biology · 2026Article
- Incidence and risk factors of monozygotic twinning following ART: analysis of 154 671 live births resulting from single embryo transfer.Human reproduction (Oxford, England) · 2025Article
- Intraovarian platelet-rich plasma injection significantly improves blastocyst yield and quality in IVF patients.Scientific reports · 2025Article
- Culture of Human Embryos at High and Low Oxygen Levels.Journal of clinical medicine · 2024Review
- The Task Matters: A Comprehensive Review and Proposed Literature Score of the Effects of Chemical and Physical Parameters on Embryo Developmental Competence.Life (Basel, Switzerland) · 2023Review
- Menstrual blood-derived mesenchymal stromal cells: impact of preconditioning on the cargo of extracellular vesicles as potential therapeutics.Stem cell research & therapy · 2023Article
- Menstrual blood-derived stromal cells: insights into their secretome in acute hypoxia conditions.Molecular medicine (Cambridge, Mass.) · 2023Article
- Biphasic oxygen tension promotes the formation of transferable blastocysts in patients without euploid embryos in previous monophasic oxygen cycles.Scientific reports · 2023Article
- "Short agonist stop" protocol, an ovarian stimulation for poor responders inFrontiers in endocrinology · 2022Article
- Ultralow Oxygen Tension (2%) Is Beneficial for Blastocyst Formation of In Vitro Human Low-Quality Embryo Culture.BioMed research international · 2022Article
- Limited Effects of Ultra-low Oxygen Concentration during Extended Embryo Culture onJournal of human reproductive sciencesArticle
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
Oxygen (O
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.