Evidence map›Paper›PMID 34789772›Full record

ArticleScientific reports2021

Modulation of cell signalling and sulfation in cardiovascular development and disease.

Tiago Justo, Antonie Martiniuc, Gurtej K Dhoot

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Tiago JustoDepartment of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, London, NW1 OTU, UK.
Antonie MartiniucDepartment of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, London, NW1 OTU, UK.
Gurtej K DhootDepartment of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, London, NW1 OTU, UK. tdhoot@rvc.ac.uk.
University of London · GBRoyal Veterinary College · GB

Funding

British Heart Foundation PG/15/78/31771British Heart Foundation, UK PG/15/78/31771Medical Research Council MR/R006237/1
6 · The paper itself

Abstract

Sulf1/Sulf2 genes are highly expressed during early fetal cardiovascular development but down-regulated during later stages correlating with a number of cell signalling pathways in a positive or a negative manner. Immunocytochemical analysis confirmed SULF1/SULF2 expression not only in endothelial cell lining of blood vessels but also in the developing cardiomyocytes but not in the adult cardiomyocytes despite persisting at reduced levels in the adult endothelial cells. The levels of both SULFs in adult ischemic human hearts and in murine hearts following coronary occlusion increased in endothelial lining of some regional blood vessels but with little or no detection in the cardiomyocytes. Unlike the normal adult heart, the levels of SULF1 and SULF2 were markedly increased in the adult canine right-atrial haemangiosarcoma correlating with increased TGFβ cell signalling. Cell signalling relationship to ischaemia was further confirmed by in vitro hypoxia of HMec1 endothelial cells demonstrating dynamic changes in not only vegf and its receptors but also sulfotransferases and Sulf1 & Sulf2 levels. In vitro hypoxia of HMec1 cells also confirmed earlier up-regulation of TGFβ cell signalling revealed by Smad2, Smad3, ALK5 and TGFβ1 changes and later down-regulation correlating with Sulf1 but not Sulf2 highlighting Sulf1/Sulf2 differences in endothelial cells under hypoxia.

Indexed as

Signal TransductionAnimalsCell HypoxiaCell LineDisease Models, AnimalDogsEndothelial CellsHeartHumansMiceMyocardial InfarctionMyocardiumSulfatasesSulfotransferasesTransforming Growth Factor betaSULF1 protein, humanSulf1 protein, mouseSULF2 protein, humanSulf2 protein, mouseSulfatasesSulfotransferasesTransforming Growth Factor beta

Identifiers

PMID34789772
PMCPMC8599478
OpenAlexW3214276605

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.