Evidence map›Paper›PMID 34789573›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Motor-independent retraction of type IV pili is governed by an inherent property of the pilus filament.

Jennifer L Chlebek, Rémi Denise, Lisa Craig, Ankur B Dalia

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 29 citations in OpenAlex.

  1. Structural modeling reveals the mechanism of motor ATPase coordination during type IV pilus retraction.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. mBio · 2026
    Article
  4. Review
  5. Separation ofmBio · 2025
    Article
  6. Integrative Structure and Function of thebioRxiv : the preprint server for biology · 2025
    Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Effect of anti-biofilm peptideFrontiers in cellular and infection microbiology · 2024
    Article
  16. Article
  17. Watching DNA uptake:Journal of bacteriology · 2023
    Article
  18. Article
  19. Mechanism of secretion of TcpF by theProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Jennifer L ChlebekDepartment of Biology, Indiana University, Bloomington, IN 47405.ORCID 0000-0002-1744-0016
Rémi DeniseMicrobial Evolutionary Genomics, CNRS UMR3525, Institut Pasteur, 75015 Paris, France.ORCID 0000-0003-2277-689X
Lisa CraigMolecular Biology and Biochemistry Department, Simon Fraser University, Burnaby BC V5A 1S6, Canada.ORCID 0000-0001-8515-9915
Ankur B DaliaDepartment of Biology, Indiana University, Bloomington, IN 47405; ankdalia@indiana.edu.ORCID 0000-0003-2203-1230
Indiana University Bloomington · USCentre National de la Recherche Scientifique · FRSimon Fraser University · CA

Funding

Mechanisms and regulation of horizontal gene transfer by natural transformation in Vibrio choleraeR35GM128674 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI Ankur Dalia · 2018 to 2026
$3.8M
NIGMS NIH HHS R35 GM128674
6 · The paper itself

Abstract

Type IV pili (T4P) are dynamic surface appendages that promote virulence, biofilm formation, horizontal gene transfer, and motility in diverse bacterial species. Pilus dynamic activity is best characterized in T4P that use distinct ATPase motors for pilus extension and retraction. Many T4P systems, however, lack a dedicated retraction motor, and the mechanism underlying this motor-independent retraction remains a mystery. Using the

Indexed as

AcinetobacterAdenosine TriphosphatasesFimbriae, BacterialFimbriae ProteinsType II Secretion SystemsVibrio choleraeVirulenceAdenosine TriphosphatasesFimbriae ProteinsType II Secretion SystemsAcinetobactertype IV filamentVibrio

Identifiers

PMID34789573
PMCPMC8617508
OpenAlexW3211844997

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.