ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
Existence of Functional Connectome Fingerprint during Infancy and Its Stability over Months.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Functional brain connectivity from the fetal period through infancy: A narrative review of resting-state fMRI studies.Developmental cognitive neuroscience · 2026Review
- Lesions Associated With Autism Symptoms Map to a Cerebellar Brain Network in Tuberous Sclerosis Complex.Annals of the Child Neurology Society · 2026Article
- The individuality of single-frame functional brain connectivity.bioRxiv : the preprint server for biology · 2026Article
- From rest to meaning: default mode network neuroscience as a design constraint for early childhood education.Frontiers in psychology · 2026Review
- Connectivity and function are coupled across cognitive domains throughout the brain.Network neuroscience (Cambridge, Mass.) · 2026Article
- Structure-function coupling in the first month of life: Associations with age and attention.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Revealing morphological fingerprints in perinatal brains using quasi-conformal mapping: occurrence and neurodevelopmental implications.Brain imaging and behavior · 2025Article
- The overgrowth of structure-function coupling in premature brain during infancy.Developmental cognitive neuroscience · 2025Article
- INDIVIDUALIZED TRAJECTORY PREDICTION OF EARLY DEVELOPING FUNCTIONAL CONNECTIVITY.Proceedings. IEEE International Symposium on Biomedical Imaging · 2025Article
- MAMBA-BASED RESIDUAL GENERATIVE ADVERSARIAL NETWORK FOR FUNCTIONAL CONNECTIVITY HARMONIZATION DURING INFANCY.Proceedings. IEEE International Symposium on Biomedical Imaging · 2025Article
- TR(Acking) Individuals Down: Exploring the Effect of Temporal Resolution in Resting-State Functional MRI Fingerprinting.Human brain mapping · 2025Article
- Individual patterns of functional connectivity in neonates as revealed by surface-based Bayesian modeling.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Local Gradients of Functional Connectivity Enable Precise Fingerprinting of Infant Brains During Dynamic Development.bioRxiv : the preprint server for biology · 2024Article
- A Subset of Cortical Areas Exhibit Adult-like Functional Network Patterns in Early Childhood.bioRxiv : the preprint server for biology · 2024Article
- Separating group- and individual-level brain signatures in the newborn functional connectome: A deep learning approach.NeuroImage · 2024Article
- Consecutive-Contrastive Spherical U-Net: Enhancing Reliability of Individualized Functional Brain Parcellation for Short-Duration fMRI Scans.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2024Article
- Constructing fine-grained spatiotemporal neonatal functional atlases with spectral functional network learning.Human brain mapping · 2024Article
- Towards personalized precision functional mapping in infancy.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Infant neuroscience: how to measure brain activity in the youngest minds.Trends in neurosciences · 2024Review
- Simulation-based inference of developmental EEG maturation with the spectral graph model.Communications physics · 2024Article
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Abstract
The functional connectome fingerprint is a cluster of individualized brain functional connectivity patterns that are capable of distinguishing one individual from others. Although its existence has been demonstrated in adolescents and adults, whether such individualized patterns exist during infancy is barely investigated despite its importance in identifying the origin of the intrinsic connectome patterns that potentially mirror distinct behavioral phenotypes. To fill this knowledge gap, capitalizing on a longitudinal high-resolution structural and resting-state functional MRI dataset with 104 human infants (53 females) with 806 longitudinal scans (age, 16-876 d) and infant-specific functional parcellation maps, we observe that the brain functional connectome fingerprint may exist since infancy and keeps stable over months during early brain development. Specifically, we achieve an ∼78% individual identification rate by using ∼5% selected functional connections, compared with the best identification rate of 60% without connection selection. The frontoparietal networks recognized as the most contributive networks in adult functional connectome fingerprinting retain their superiority in infants despite being widely acknowledged as rapidly developing systems during childhood. The existence and stability of the functional connectome fingerprint are further validated on adjacent age groups. Moreover, we show that the infant frontoparietal networks can reach similar accuracy in predicting individual early learning composite scores as the whole-brain connectome, again resembling the observations in adults and highlighting the relevance of functional connectome fingerprint to cognitive performance. For the first time, these results suggest that each individual may retain a unique and stable marker of functional connectome during early brain development.
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