Evidence map›Paper›PMID 34789514›Full record

ArticleCold Spring Harbor molecular case studies2021

Transient myeloproliferative disorder as the presenting feature for mosaic trisomy 21.

Nicole Baca, Pedro A Sanchez-Lara, Rhona Schreck, Celeste C Eno, Fataneh Majlessipour

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cold Spring Harbor molecular case studies, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Nicole BacaCedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Pedro A Sanchez-LaraCedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Rhona SchreckCedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Celeste C EnoCedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Fataneh MajlessipourCedars-Sinai Medical Center, Los Angeles, California 90048, USA.
University of California, Los Angeles · USCedars-Sinai Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trisomy 21 is a common congenital disorder with well-documented clinical manifestations, including an increased risk for the transient myeloproliferative disorder as a neonate and leukemia in childhood and adolescence. Transient myeloproliferative disorder is only known to occur in hematopoietic cells with trisomy 21. Children with mosaic trisomy 21 also have a risk for hematological malignancies. We present a nondysmorphic neonate, with a negative noninvasive prenatal screening of maternal blood for trisomy 21, who came to medical attention because of ruddy skin. He was found to have mild polycythemia, thrombocytopenia, and developed peripheral blasts. His clinical presentation was consistent with transient myeloproliferative disorder, which is only seen with trisomy 21. Cytogenetic studies of peripheral blood are positive for mosaic trisomy 21.

Indexed as

Down SyndromeMyeloproliferative DisordersChromosomes, Human, Pair 21FemaleHumansMaleMosaicismPregnancyTrisomyUniparental Disomyextramedullary hematopoiesishematological neoplasm

Identifiers

PMID34789514
PMCPMC8751406
OpenAlexW3211754427

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.