ReviewDeutsches Arzteblatt international2021
Multiresistant Gram-Negative Pathogens—A Zoonotic Problem.
Review in Deutsches Arzteblatt international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Third-generation cephalosporin resistant Escherichia coli in dogs and cats in Germany in 2019-2021.PloS one · 2024Article
- Zoonotic sources and the spread of antimicrobial resistance from the perspective of low and middle-income countries.Infectious diseases of poverty · 2023Review
- [Health risks from crop irrigation with treated wastewater containing antibiotic residues, resistance genes, and resistant microorganisms].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2023Review
- Epidemiology and zoonotic transmission ofFrontiers in microbiology · 2023Article
- Gram-Negative Bacteria With 3MRGN Resistance Phenotype in Hospital Wastewater, Receiving Water Channels, and Sewage Plant Outlets in the Leipzig Metropolitan Area.Deutsches Arzteblatt international · 2022Article
- Occurrence and Characteristics of ESBL- and Carbapenemase- ProducingMicroorganisms · 2022Article
- The Consequences of Antibiotic Use in Human Beings and in Domestic and Farm Animals.Deutsches Arzteblatt international · 2021Article
- Multiresistant Bacteria Isolated from Intestinal Faeces of Farm Animals in Austria.Antibiotics (Basel, Switzerland) · 2021Article
- Mobile Genetic Elements Drive Antimicrobial Resistance Gene Spread inFrontiers in microbiology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExtended-spectrum-β-lactamase-producing, carbapenemase-producing, and colistin-resistant Enterobacterales (ESBL-E, CPE, and Col-E) are multiresistant pathogens that are increasingly being encountered in both human and veterinary medicine. In this review, we discuss the frequency, sources, and significance of the zoonotic transmission of these pathogens between animals and human beings.
methodsThis review is based on pertinent publications retrieved by a selective literature search. Findings for Germany are presented in the global context.
resultsESBL-E are common in Germany in both animals and human beings, with a 6-10% colonization rate in the general human population. A major source of ESBL-E is human-to-human transmission, partly through travel. Some colonizations are of zoonotic origin (i.e., brought about by contact with animals or animal-derived food products); in the Netherlands, more than 20% of cases are thought to be of this type. CPE infections, on the other hand, are rare in Germany in both animals and human beings. Their main source in human beings is nosocomial transmission. Col-E, which bear mcr resistance genes, have been described in Germany mainly in food-producing animals and their meat. No representative data are available on Col-E in human beings in Germany; in Europe, the prevalence of colonization is less than 2%, with long-distance travel as a risk factor. The relevance of animals as a source of Col-E for human beings is not yet entirely clear.
conclusionLivestock farming and animal contact affect human colonization with the multiresistant Gram-negative pathogens CPE, ESBL-E and Col-E to differing extents. Improved prevention will require the joint efforts of human and veterinary medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.