Evidence map›Paper›PMID 34789295›Full record

ArticleTrials2021

A protocol for developing a core outcome set for ectopic pregnancy.

Krystle Y Chong, Sarah Solangon, James Kemper, Kurt Barnhart, Pamela Causa Andrieu, Perrine Capmas, Carolina Chacon, George Condous, Liesl de Waard, James M N Duffy and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Krystle Y ChongMonash Women's, Monash Health, Clayton, Australia. drkrystlechong@gmail.com.ORCID http://orcid.org/0000-0002-8558-0491
Sarah SolangonInstitute for Women's Health, University College London, London, UK.
James KemperMonash Women's, Monash Health, Clayton, Australia.
Kurt BarnhartDepartment of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Penn Medicine/University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Pamela Causa AndrieuDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA.
Perrine CapmasDepartment of obstetrics and Gynecology, Bicetre University Hospital, Paris Saclay University, Le Kremlin Bicêtre, France.
Carolina ChaconRadiology Service, Hospital Italiano de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina.
George CondousAcute Gynaecology, Early Pregnancy and Advanced Endosurgery Unit, Sydney Medical School Nepean, University of Sydney, Nepean Hospital, Camperdown, NSW, Australia.
Liesl de WaardDepartment of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
James M N DuffyInstitute for Women's Health, University College London, London, UK.
Andrew HorneMRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, EH16 4TJ, UK.
Maria MemtsaInstitute for Women's Health, University College London, London, UK.
Femke MolCenter for Reproductive Medicine, Amsterdam Reproduction & Development Research Institute, Amsterdam, UMC, Netherlands.
Munira OzaThe Ectopic Pregnancy Trust, London, UK.
Annika StrandellDepartment of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Madelon van WelyCenter for Reproductive Medicine, Amsterdam Reproduction & Development Research Institute, Amsterdam, UMC, Netherlands.
Janneke Van't HooftDepartment of Obstetrics and Gynaecology, Amsterdam UMC, Amsterdam, The Netherlands.
Lan N VuongDepartment of Obstetrics and Gynecology, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam.
Jian ZhangDepartment of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Davor JurkovicInstitute for Women's Health, University College London, London, UK.
Ben W MolMonash Women's, Monash Health, Clayton, Australia.
International Collaboration on Core Outcomes in Ectopic Pregnancy

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundRandomised controlled trials (RCTs) evaluating ectopic pregnancy have reported many different outcomes, which are themselves often defined and measured in distinct ways. This level of variation results in an inability to compare results of individual RCTs. The development of a core outcome set to ensure outcomes important to key stakeholders are collected consistently will guide future research in ectopic pregnancy. STUDY

aimTo develop and implement a core outcome set to guide future research in ectopic pregnancy. METHODS AND ANALYSIS: We have established an international steering group of key stakeholders, including healthcare professionals, researchers, and individuals with lived experience of ectopic pregnancy. We will identify potential outcomes from ectopic pregnancy from a comprehensive literature review of published randomised controlled trials. We will then utilise a modified Delphi method to prioritise outcomes. Subsequently, key stakeholders will be invited to score potential core outcomes on a nine-point Likert scale, ranging from 1 (not important) to 9 (critical). Repeated reflection and rescoring should promote whole and individual stakeholder group convergence towards consensus 'core' outcomes. We will also establish standardised definitions and recommend high-quality measurements for individual core outcomes.

trial registrationCOMET 1492 . Registered in November 2019.

Indexed as

Pregnancy, EctopicResearch DesignConsensusDelphi TechniqueFemaleHumansOutcome Assessment, Health CarePregnancyTreatment OutcomeConsensus studyCore outcome setEctopic pregnancyModified Delphi methodRandomised controlled trials

Identifiers

PMID34789295
PMCPMC8596090

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.