ArticleRespiratory research2021
Knockdown of circFOXO3 ameliorates cigarette smoke-induced lung injury in mice.
Article in Respiratory research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Cigarette smoke-induced circFOXO3 upregulation enhances autophagy-regulated senescence of type II alveolar cells through interacting with E2F1.Tobacco induced diseases · 2026Article
- Adipose-derived mesenchymal stem cell-derived extracellular vesicles carry microRNA-214-3p to target GSTZ1 to curb ferroptosis in lung epithelial cells during sepsis.Cytotechnology · 2025Article
- Research progress of circular RNA FOXO3 in diseases (review).Global medical genetics · 2025Review
- Noncoding RNAs in chronic obstructive pulmonary disease: From pathogenesis to therapeutic targets.Non-coding RNA research · 2024Review
- Circular RNAs in human diseases.MedComm · 2024Review
- CircRNA: a rising therapeutic strategy for lung injury induced by pulmonary toxicants.Archives of toxicology · 2024Review
- Circular RNA CircFOXO3 Functions as a Competitive Endogenous RNA for Acid-Sensing Ion Channel Subunit 1 Mediating Oxeiptosis in Nucleus Pulposus.Biomedicines · 2024Article
- Circular RNAs in glioma: Molecular functions and pathological implications.Non-coding RNA research · 2024Review
- Circular RNA_0025843 Alleviated Cigarette Smoke Extract Induced Bronchoalveolar Epithelial Cells Ferroptosis.International journal of chronic obstructive pulmonary disease · 2024Article
- Circular RNA Expression of Peripheral Blood Mononuclear Cells Associated with Risk of Acute Exacerbation in Smoking Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2024Article
- Functional roles of circular RNAs in lung injury.Frontiers in pharmacology · 2024Review
- Role of circRMRP and circRPL27 in chronic obstructive pulmonary disease.Open life sciences · 2024Article
- Systematic analysis of various RNA transcripts and construction of biological regulatory networks at the post-transcriptional level for chronic obstructive pulmonary disease.Journal of translational medicine · 2023Article
- Significant role of circRNA BBS9 in chronic obstructive pulmonary disease via miRNA-103a-3p/BCL2L13.BMC pulmonary medicine · 2023Article
- Identification and bioinformatic analysis of CircRNAs in the plasma of patients with very severe chronic obstructive pulmonary disease.BMC pulmonary medicine · 2023Article
- Roles of noncoding RNAs in chronic obstructive pulmonary disease.Journal of translational internal medicine · 2023Article
- A Diagnostic Classifier Based on Circulating miRNA Pairs for COPD Using a Machine Learning Approach.Diagnostics (Basel, Switzerland) · 2023Article
- Circular RNAs: emerging players in asthma and COPD.Frontiers in cell and developmental biology · 2023Review
- Circular RNAs in organ injury: recent development.Journal of translational medicine · 2022Review
- Prediction of COPD acute exacerbation in response to air pollution using exosomal circRNA profile and Machine learning.Environment international · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundChronic obstructive pulmonary disease (COPD) remains a prevalent chronic airway inflammatory disease. Circular RNAs (circRNAs) are associated with inflammation regulation; therefore, we examined distinct effects of circRNA FOXO3 (circFOXO3) against pneumonic inflammatory processes in COPD.
methodsWe first quantified and localized circFOXO3 in mouse lung epithelial cell line MLE12 by quantitative reverse-transcription PCR and in situ hybridization. Next, circFOXO3 was suppressed by therapeutic administration of circFOXO3 knockdown lentivirus in mice exposed to air or cigarette smoke (CS) for 12 weeks, and several hallmarks of COPD were evaluated.
resultsWe noticed that circFOXO3 is upregulated in CS-exposed lungs and cigarette smoke extract (CSE)-treated murine alveolar epithelial cells. Knockdown of circFOXO3 attenuated the release of CXCL1 and IL-6 as well as inflammatory processes in the lungs of CS-exposed mice. In addition, we identified miR-214-3p as a circFOXO3-targeted microRNA. MiR-214-3p overexpression exerted protective effects against pneumonic inflammation after CS exposure. Silencing of circFOXO3 downregulated IKK-β mRNA (miR-214-3p's target), resulting in the dysfunction of the NF-κB signaling pathway and attenuation of CSE-induced inflammatory-cytokine expression.
conclusionsCollectively, these findings reveal a crucial function of circFOXO3 in the pathological remodeling related to CS-induced inflammatory processes. Hence, circFOXO3 might be a good target for the treatment of inflammatory disorders similar to CS-induced lung inflammation.
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