Evidence map›Paper›PMID 34789193›Full record

ArticleBMC neurology2021

Miller Fisher syndrome following BNT162b2 mRNA coronavirus 2019 vaccination.

Yamato Nishiguchi, Hirofumi Matsuyama, Kuniko Maeda, Akihiro Shindo, Hidekazu Tomimoto

Open access · goldAbstract readCase Reports
In one paragraph

Article in BMC neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 4 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
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  5. Article
  6. The spectrum of anti-GQ1B antibody syndrome: beyond Miller Fisher syndrome and Bickerstaff brainstem encephalitis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Review
  7. Review
  8. [Miller-Fisher/Guillain-Barré overlap syndrome following COVID-19 vaccination].Revista medica del Instituto Mexicano del Seguro Social · 2024
    Article
  9. Neuro-Ophthalmic Complications of COVID-19 Infection and Vaccination.Advances in ophthalmology and optometry · 2023
    Review
  10. Review
  11. Review
  12. Ocular motility disorders following coronavirus disease-19 vaccination.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023
    Article
  13. Article
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  15. Post-COVID-19 Vaccination CNS Magnetic Resonance Imaging Findings: A Systematic Review.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yamato NishiguchiDepartment of Neurology, Graduate School of Medicine, Mie University, Tsu, Mie, 514-8507, Japan. yamato.nishi.1008@gmail.com.ORCID http://orcid.org/0000-0002-8034-2670
Hirofumi MatsuyamaDepartment of Neurology, Graduate School of Medicine, Mie University, Tsu, Mie, 514-8507, Japan.
Kuniko MaedaDepartment of Ophthalmology, Mie Prefectural Shima Hospital, Shima, Mie, 517-0595, Japan.
Akihiro ShindoDepartment of Neurology, Graduate School of Medicine, Mie University, Tsu, Mie, 514-8507, Japan.
Hidekazu TomimotoDepartment of Neurology, Graduate School of Medicine, Mie University, Tsu, Mie, 514-8507, Japan.
Mie University · JPShimane Prefectural Central Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), began in late 2019. One of the vaccines approved against COVID-19 is the BNT162b2 mRNA COVID-19 vaccine (Pfizer/BioNTech). CASE PRESENTATION: We present the case of a 71-year-old man with no history of the SARS-CoV-2 infection or any recent viral or bacterial illnesses who presented with bilateral oculomotor palsy and limb ataxia after BNT162b2 mRNA COVID-19 vaccination. The diagnosis of Miller Fisher syndrome (MFS) was established based on physical examination, brain magnetic resonance imaging (MRI), cerebrospinal fluid analysis (CSF), and positron emission tomography (PET). There was no evidence of other predisposing infectious or autoimmune factors, and the period from COVID-19 vaccination to the appearance of neurological symptoms was similar to that of other vaccines and preceding events, such as infection.

conclusionGuillain-Barré syndrome (GBS) and its variants after COVID-19 vaccination are extremely rare. Note that more research is needed to establish an association between MFS and COVID-19 vaccines. In our opinion, the benefits of COVID-19 vaccination largely outweigh its risks.

Indexed as

COVID-19Miller Fisher SyndromeAgedBNT162 VaccineCOVID-19 VaccinesHumansMaleRNA, MessengerSARS-CoV-2VaccinationBNT162 VaccineCOVID-19 VaccinesRNA, MessengerCOVID-19Guillain–Barré syndromeMiller fisher syndromeSARS-CoV-2Vaccination

Identifiers

PMID34789193
PMCPMC8598937
OpenAlexW3213539967

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.