ArticleBMC pregnancy and childbirth2021
Changes in fatty acid levels (saturated, monounsaturated and polyunsaturated) during pregnancy.
Article in BMC pregnancy and childbirth, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Altered Maternal Fatty Acid Signature and Placental Transfer in Gestational Diabetes Mellitus: The Role of Fatty Acid Indices.Nutrients · 2026Article
- AMPK: Accumulating Evidence in Support of its role in Dual Regulation of Vascular Function and Metabolism During Human Pregnancy.Acta physiologica (Oxford, England) · 2025Review
- Human ovulatory phase-increasing odors cause positive emotions and stress-suppressive effects in males.iScience · 2025Article
- Enhancing clinical detection of polyunsaturated fatty acids (PUFAs) in pregnancy: a robust LC-MS/MS methodology.Bioanalysis · 2025Article
- Lipid imbalance and inflammatory oxylipin cascade at the maternal-fetal interface in recurrent spontaneous abortion.Heliyon · 2024Article
- Vitamin D and LC-PUFA and the Presence of Fetal Heart Defects-A Further Part of a Case-Control Study.Nutrients · 2024Article
- Disrupted Prenatal Metabolism May Explain the Etiology of Suboptimal Neurodevelopment: A Focus on Phthalates and Micronutrients and their Relationship to Autism Spectrum Disorder.Advances in nutrition (Bethesda, Md.) · 2024Review
- Gestational testosterone excess early to mid-pregnancy disrupts maternal lipid homeostasis and activates biosynthesis of phosphoinositides and phosphatidylethanolamines in sheep.Scientific reports · 2024Article
- Docosahexaenoic Acid Supplementation in Lactating Women Increases Breast Milk and Erythrocyte Membrane Docosahexaenoic Acid Concentrations and Alters Infant n-6:n-3 Fatty Acid Ratio.Current developments in nutrition · 2023Article
- Role of functional fatty acids in modulation of reproductive potential in livestock.Journal of animal science and biotechnology · 2023Review
- Nonsteroidal anti-inflammatory drugs and implications for the cyclooxygenase pathway in embryonic development.American journal of physiology. Cell physiology · 2023Review
- Metabolomics during canine pregnancy and lactation.PloS one · 2023Article
- Immunobiography and women's health: repercussions from conception to senility.Revista da Associacao Medica Brasileira (1992) · 2023Article
- Caffeine Intake throughout Pregnancy, and Factors Associated with Non-Compliance with Recommendations: A Cohort Study.Nutrients · 2022Article
- Adapting prenatal iron supplementation to maternal needs results in optimal child neurodevelopment: a follow-up of the ECLIPSES Study.BMC pregnancy and childbirth · 2022Article
- The interplay between the gut microbiota and metabolism during the third trimester of pregnancy.Frontiers in microbiology · 2022Article
- Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring pregnancy a high amount of fatty acids (FA) is necessary to meet foetus demands, which vary during gestation. The present study describes the changes in maternal fatty acid concentrations during pregnancy in a sample of pregnant women.
methodsThis is a longitudinal study of 479 pregnant women who were monitored from the first trimester to third trimester of pregnancy. Data on maternal characteristics were recorded and a serum sample was collected in each trimester. The fatty acid profile (saturated (SFA: total, lauric acid, myristic acid, palmitic acid, stearic acid), monounsaturated (MUFA: total, palmitoleic acid, oleic acid) and polyunsaturated fatty acids (PUFA: total omega-6 (n-6), linoleic acid, dihomo-γ-linolenic acid, arachidonic acid (AA), total omega-3 (n-3), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA)) was analysed with a gas chromatography-mass spectrometry combination.
resultsFrom the first trimester to third trimester of pregnancy, a significant increase in total SFA, total MUFA and total n-6 PUFA was found. (p < 0.001). Nevertheless, the serum concentration of arachidonic acid (AA), eicosapentaenoic acid (EPA) and total n-3 PUFA decreased during gestation (p < 0.001). A statistically non-significant result was observed for the docosahexaenoic acid (DHA) serum concentration between the first and third trimesters of pregnancy. Significant correlations were observed between each total fatty acid concentrations of the first and third trimesters.
conclusionThe circulating serum concentration of SFA, MUFA and n-6 PUFA increases during pregnancy, whereas essential fatty acids such as AA and EPA decrease, and DHA remains unchanged. Further research is necessary to understand the role played by FA throughout gestation.
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