Evidence map›Paper›PMID 34789006›Full record

ArticleCancer control : journal of the Moffitt Cancer Center

Clinicopathological Variables and Outcome in Chronic Myeloid Leukemia Associated With BCR-ABL1 Transcript Type and Body Weight: An Outcome of European LeukemiaNet Project.

Mohammad A J Abdulla, Prem Chandra, Susanna El Akiki, Mahmood B Aldapt, Sundus Sardar, Ammar Chapra, Abdulqadir J Nashwan, Claudio Sorio, Luisa Tomasello, Christian Boni and 1 more

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Article in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mohammad A J AbdullaDepartment of Medical Oncology, Hematology Section, National Center for Cancer Care and Research, 36977Hamad Medical Corporation, Doha, Qatar.
Prem ChandraMedical Research Center, Biostatistics Section, 36977Hamad Medical Corporation, Doha, Qatar.
Susanna El AkikiDepartment of Laboratory Medicine and Pathology, 36977Hamad Medical Corporation, Doha, Qatar.
Mahmood B AldaptDepartment of Medical Oncology, Hematology Section, National Center for Cancer Care and Research, 36977Hamad Medical Corporation, Doha, Qatar.
Sundus SardarDepartment of Internal Medicine, 36977Hamad Medical Corporation, Doha, Qatar.
Ammar ChapraDepartment of Internal Medicine, 36977Hamad Medical Corporation, Doha, Qatar.
Abdulqadir J NashwanDepartment of Nursing, Hazm Mebaireek General Hospital, 36977Hamad Medical Corporation, Doha, Qatar.
Claudio SorioUniversity of Verona, Verona, Italy.
Luisa TomaselloOhio State University, Columbus, Ohio, USA.
Christian BoniUniversity of Verona, Verona, Italy.
Mohamed A YassinDepartment of Medical Oncology, Hematology Section, National Center for Cancer Care and Research, 36977Hamad Medical Corporation, Doha, Qatar.ORCID https://orcid.org/0000-0002-1144-8076

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIt is debatable whether BCR-ABL1 transcript type has an impact on outcome of treatment of patients with CML, and it is not widely studied whether body weight influences response to treatment. In this study, we tried to find out if any of these factors has an impact on response to treatment and outcome. METHODOLOGY: We conducted a retrospective analysis of the files of 79 patients being treated in our center for CML with known BCR-ABL1 breakpoints, and patients' management and response assessment was done based on ELN 2013 guidelines. The analysis was performed based on two main groups, obese vs. normal BMI, and then based on BCR-ABL1 transcripts: e13a2 vs. e14a2. Cumulative incidence of MMR, CCyR, and DMR were estimated using the Kaplan-Meier survival curve method, and comparisons between groups were performed by the Log-rank/Gray test methods. RESULTS/

conclusionIn the patient-cohort studied, there was no statistically significant difference in molecular response between patients with CML based on body weight or transcript type although patients in the obesity group achieved higher and faster MMR with no statistical significance.

Indexed as

AdultAgedBody WeightFemaleFusion Proteins, bcr-ablHumansKaplan-Meier EstimateLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMaleMiddle AgedObesityRetrospective StudiesSociodemographic FactorsYoung AdultBCR-ABL1 fusion protein, humanFusion Proteins, bcr-ablBCR-ABL1 transcriptchronic myeloid leukemiaobesity

Identifiers

PMID34789006
PMCPMC8619745

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.