ArticleClinical endoscopy2021
Predictive Factors for Differentiating Gastrointestinal Stromal Tumors from Leiomyomas Based on Endoscopic Ultrasonography Findings in Patients with Gastric Subepithelial Tumors: A Multicenter Retrospective Study.
Article in Clinical endoscopy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Feasibility and diagnostic performance of heparinized wetsuction and single-pass single-needle actuation endoscopic ultrasound-guided tissue acquisition for subepithelial lesions in Japan: a single-center retrospective study.Clinical endoscopy · 2026Article
- Development and validation of an endoscopic ultrasound-based nomogram for differentiating small gastric stromal tumours from non-gastric stroma tumours.Surgical endoscopy · 2026Article
- A novel risk-scoring system based on endoscopic ultrasound and clinical characteristics for the preoperative diagnosis of small gastric gastrointestinal stromal tumors.Scientific reports · 2026Article
- Nationwide Multicenter Study of Advanced Endoscopic Resection and Malignant Risk Model for Gastric Myogenic Tumors (GASTRO Trial).Life (Basel, Switzerland) · 2026Article
- The clinical value of endoscopic ultrasonography combined with endoscopic treatment for upper gastrointestinal lifting lesions.Frontiers in medicine · 2026Article
- Uncovering the associative mediation pathway from EUS features to malignancy through pathological mediators in gastrointestinal stromal tumor.Frontiers in medicine · 2026Article
- Diagnosis model for gastric submucosal tumor based on multiple decision trees comprising endoscopic and endoscopic ultrasonography features.BMC gastroenterology · 2025Article
- Diagnostic accuracy and influencing factors of microprobe endoscopic ultrasound for gastrointestinal subepithelial lesions: a multicenter retrospective study.BMC gastroenterology · 2025Article
- Advancements in endoscopic resection of subepithelial tumors: toward safer, recurrence-free techniques.Clinical endoscopy · 2025Article
- Differential diagnosis of gastrointestinal stromal tumors versus leiomyomas by special stains.BMC gastroenterology · 2024Article
- Diagnostic Endoscopic Ultrasound (EUS) of the Luminal Gastrointestinal Tract.Diagnostics (Basel, Switzerland) · 2024Review
- Prevalence, natural progression, and clinical practices of upper gastrointestinal subepithelial lesions in Korea: a multicenter study.Clinical endoscopy · 2023Article
- Endoscopic ultrasound artificial intelligence-assisted for prediction of gastrointestinal stromal tumors diagnosis: A systematic review and meta-analysis.World journal of gastrointestinal endoscopy · 2023Article
- Endoscopic Ultrasound Advanced Techniques for Diagnosis of Gastrointestinal Stromal Tumours.Cancers · 2023Review
- The Diagnosis of Small Gastrointestinal Subepithelial Lesions by Endoscopic Ultrasound-Guided Fine Needle Aspiration and Biopsy.Diagnostics (Basel, Switzerland) · 2022Review
- Long-term prognosis and risk factor-based surveillance strategy for patients with small gastric subepithelial lesion using endoscopic ultrasonography.Endoscopic ultrasoundArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
BACKGROUND/
aimsThe utility of endoscopic ultrasonography (EUS) for differentiating gastrointestinal stromal tumors (GISTs) and leiomyomas of the stomach is not well known. We aimed to evaluate the ability of EUS for differentiating gastric GISTs and leiomyomas.
methodsWe retrospectively reviewed the medical records of patients with histopathologically proven GISTs (n=274) and leiomyomas (n=87). In two consensus meetings, the inter-observer variability in the EUS image analysis was reduced. Using logistic regression analyses, we selected predictive factors and constructed a predictive model and nomogram for differentiating GISTs from leiomyomas. A receiver operating characteristic (ROC) curve analysis was performed to measure the discrimination performance in the development and internal validation sets.
resultsMultivariate analysis identified heterogeneity (odds ratio [OR], 9.48), non-cardia (OR, 19.11), and older age (OR, 1.06) as independent predictors of GISTs. The areas under the ROC curve of the predictive model using age, sex, and four EUS factors (homogeneity, location, anechoic spaces, and dimpling or ulcer) were 0.916 (sensitivity, 0.908; specificity, 0.793) and 0.904 (sensitivity, 0.908; specificity, 0.782) in the development and internal validation sets, respectively.
conclusionThe predictive model and nomogram using age, sex and homogeneity, tumor location, presence of anechoic spaces, and presence of dimpling or ulcer on EUS may facilitate differentiation between GISTs and leiomyomas.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.