Evidence map›Paper›PMID 34788826›Full record

ArticleNucleic acids research2022

PHI-base in 2022: a multi-species phenotype database for Pathogen-Host Interactions.

Martin Urban, Alayne Cuzick, James Seager, Valerie Wood, Kim Rutherford, Shilpa Yagwakote Venkatesh, Jashobanta Sahu, S Vijaylakshmi Iyer, Lokanath Khamari, Nishadi De Silva and 4 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed.

  1. Article
  2. Time-Course Comparative Transcriptomics Between Isolates ofJournal of fungi (Basel, Switzerland) · 2026
    Article
  3. Genome assembly and annotation ofMicrobiology resource announcements · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Journal of fungi (Basel, Switzerland) · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Increased pathogens and reduced intestinal immune genes associated with fish diseases during the winter-spring transition.International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Article
  17. Article
  18. Review
  19. Draft genome sequence of3 Biotech · 2025
    Article
  20. Article

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Martin UrbanDepartment of Biointeractions and Crop Protection, Rothamsted Research, Harpenden AL5 2JQ, UK.ORCID 0000-0003-2440-4352
Alayne CuzickDepartment of Biointeractions and Crop Protection, Rothamsted Research, Harpenden AL5 2JQ, UK.ORCID 0000-0001-8941-3984
James SeagerDepartment of Biointeractions and Crop Protection, Rothamsted Research, Harpenden AL5 2JQ, UK.ORCID 0000-0001-7487-610X
Valerie WoodDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.ORCID 0000-0001-6330-7526
Kim RutherfordDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.ORCID 0000-0001-6277-726X
Shilpa Yagwakote VenkateshMolecular Connections, Kandala Mansions, Kariappa Road, Basavanagudi, Bengaluru 560 004, India.
Jashobanta SahuMolecular Connections, Kandala Mansions, Kariappa Road, Basavanagudi, Bengaluru 560 004, India.
S Vijaylakshmi IyerMolecular Connections, Kandala Mansions, Kariappa Road, Basavanagudi, Bengaluru 560 004, India.
Lokanath KhamariMolecular Connections, Kandala Mansions, Kariappa Road, Basavanagudi, Bengaluru 560 004, India.
Nishadi De SilvaEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.ORCID 0000-0003-4802-2375
Manuel Carbajo MartinezEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Helder PedroEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.ORCID 0000-0001-7582-1565
Andrew D YatesEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.ORCID 0000-0002-8886-4772
Kim E Hammond-KosackDepartment of Biointeractions and Crop Protection, Rothamsted Research, Harpenden AL5 2JQ, UK.ORCID 0000-0002-9699-485X

Funding

Biotechnology and Biological Sciences Research Council BB/I001077/1Biotechnology and Biological Sciences Research Council BB/K020102/1Biotechnology and Biological Sciences Research Council BB/P016855/1Biotechnology and Biological Sciences Research Council BB/S020020/1Biotechnology and Biological Sciences Research Council BB/S02011X/1Wellcome TrustWellcome Trust 108749/Z/15/Z
6 · The paper itself

Abstract

Since 2005, the Pathogen-Host Interactions Database (PHI-base) has manually curated experimentally verified pathogenicity, virulence and effector genes from fungal, bacterial and protist pathogens, which infect animal, plant, fish, insect and/or fungal hosts. PHI-base (www.phi-base.org) is devoted to the identification and presentation of phenotype information on pathogenicity and effector genes and their host interactions. Specific gene alterations that did not alter the in host interaction phenotype are also presented. PHI-base is invaluable for comparative analyses and for the discovery of candidate targets in medically and agronomically important species for intervention. Version 4.12 (September 2021) contains 4387 references, and provides information on 8411 genes from 279 pathogens, tested on 228 hosts in 18, 190 interactions. This provides a 24% increase in gene content since Version 4.8 (September 2019). Bacterial and fungal pathogens represent the majority of the interaction data, with a 54:46 split of entries, whilst protists, protozoa, nematodes and insects represent 3.6% of entries. Host species consist of approximately 54% plants and 46% others of medical, veterinary and/or environmental importance. PHI-base data is disseminated to UniProtKB, FungiDB and Ensembl Genomes. PHI-base will migrate to a new gene-centric version (version 5.0) in early 2022. This major development is briefly described.

Indexed as

Databases, FactualPhenotypeUser-Computer InterfaceAnimalsApicomplexaBacteriaDiplomonadidaFungiHost-Pathogen InteractionsInsectaInternetNematodaPhylogenyPlantsVirulence

Identifiers

PMID34788826
PMCPMC8728202

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.