Evidence map›Paper›PMID 34788808›Full record

ReviewClinical infectious diseases : an official publication of the Infectious Diseases Society of America2022

Syphilis Testing and Diagnosis Among People With Human Immunodeficiency Virus (HIV) Engaged in Care at 4 US Clinical Sites, 2014-2018.

Timothy W Menza, Stephen A Berry, Julie Dombrowski, Edward Cachay, Jodie Dionne-Odom, Katerina Christopoulos, Heidi M Crane, Mari M Kitahata, Kenneth H Mayer

Open access · greenAbstract readReview
In one paragraph

Review in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Mpox in People With HIV: Predictors of Diagnosis, Outcomes, and Vaccine Effectiveness in a Multisite Cohort.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Potential impact of doxycycline post-exposure prophylaxis prescribing strategies on incidence of bacterial sexually transmitted infections.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  8. Observational
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Timothy W MenzaOregon Health and Science University, Portland, Oregon, USA.ORCID 0000-0003-4154-7718
Stephen A BerryJohns Hopkins School of Medicine, Baltimore, Maryland, USA.
Julie DombrowskiUniversity of Washington School of Medicine, Seattle, Washington, USA.
Edward CachayUniversity of California-San Diego School of Medicine, San Diego, California, USA.
Jodie Dionne-OdomUniversity of Alabama School of Medicine, Birmingham, Alabama, USA.
Katerina ChristopoulosUniversity of California-San Francisco School of Medicine, San Francisco, California, USA.
Heidi M CraneUniversity of Washington School of Medicine, Seattle, Washington, USA.
Mari M KitahataUniversity of Washington School of Medicine, Seattle, Washington, USA.
Kenneth H MayerHarvard Medical School, Boston, Massachusetts, USAand.
University of Washington · USHarvard University · USJohns Hopkins University · USOregon Health Authority · USUniversity of Alabama at Birmingham · USUniversity of California San Diego · USUniversity of California, San Francisco · US

Funding

Unsolicited R24 for the CFAR-Network of Integrated Clinical Sciences, CNICSR24AI067039 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael S. Saag · 2006 to 2026
$99.4M
NIAID NIH HHS R24 AI067039
6 · The paper itself

Abstract

backgroundDespite rising rates of syphilis among people with human immunodeficiency virus (HIV; PWH) in the United States, there is no optimal syphilis screening frequency or prioritization.

methodsWe reviewed records of all PWH in care between 1 January 2014 and 16 November 2018 from 4 sites in the Centers for AIDS Research Network of Integrated Clinical Systems Cohort (CNICS; N = 8455). We calculated rates of syphilis testing and incident syphilis and used Cox proportional hazards models modified for recurrent events to examine demographic and clinical predictors of testing and diagnosis.

resultsParticipants contributed 29 568 person-years of follow-up. The rate of syphilis testing was 118 tests per 100 person-years (95% confidence interval [CI]: 117-119). The rate of incident syphilis was 4.7 cases per 100 person-years (95% CI: 4.5-5.0). Syphilis diagnosis rates were highest among younger cisgender men who have sex with men and transgender women, Hispanic individuals, people who inject drugs, and those with detectable HIV RNA, rectal infections, and hepatitis C.

conclusionsWe identified PWH who may benefit from more frequent syphilis testing and interventions for syphilis prevention.

Indexed as

HIV InfectionsSexual and Gender MinoritiesSyphilisFemaleHIVHomosexuality, MaleHumansIncidenceMaleRisk FactorsUnited Statespeople living with HIVsyphilis incidencesyphilis testing

Identifiers

PMID34788808
PMCPMC9427144
OpenAlexW3211450212

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.