ArticleThe journal of allergy and clinical immunology. In practice2022
Association of Growth Trajectory Profiles with Asthma Development in Infants Hospitalized with Bronchiolitis.
Article in The journal of allergy and clinical immunology. In practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Body mass index trajectories may represent modifiable targets in the promotion of respiratory health.The European respiratory journal · 2025Article
- Defining longitudinal trajectory of body mass index percentile and predicting childhood obesity: methodologies and findings in the Boston Birth Cohort.Precision nutrition · 2023Article
- Application of Metabolomics in Obesity-Related Childhood Asthma Subtyping: A Narrative Scoping Review.Metabolites · 2023Article
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8 authors.
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Abstract
backgroundLittle is known about the relationship of longitudinal growth trajectory in early life with asthma development, particularly in infants with bronchiolitis (a high-risk population).
objectiveAmong infants with bronchiolitis, we aimed to identify growth trajectory profiles and determine their longitudinal relationship with the risk for developing childhood asthma.
methodsA multicenter prospective study enrolled infants (aged <1 year) hospitalized for bronchiolitis. We identified growth trajectory profiles-derived from body mass index-for-age at ages 0, 6, 12, 15, 18, 24, and 36 months by using a longitudinal clustering method. We examined associations between growth trajectory profiles and asthma development by age 5 years.
resultsThe analytic cohort consists of 880 infants hospitalized for bronchiolitis (median age, 3 months). Overall, 26% developed asthma by age 5 years. The longitudinal clustering identified 5 distinct profiles: persistent low growth (27%), normative growth (33%), transient overweight (21%), late-onset overweight (16%), and persistent obesity (3%) profiles. In multivariable model, compared with children with a normative profile, those with a persistent obesity profile had significantly higher risks of developing asthma (24% vs 38%, odds ratio [OR]: 2.55, 95% confidence interval [CI]: 1.07-6.09, P = .03). Among children with a persistent obesity profile, those without allergic predisposition had significantly higher risks of asthma (OR: 3.02, 95% CI: 1.05-8.64, P = .04 in the nonparental allergic history group; OR: 3.18, 95% CI: 1.02-9.92, P = .047 in the non-IgE sensitization group), whereas those with allergic predisposition were not at increased risk.
conclusionsThis multicenter cohort study of infants with bronchiolitis demonstrated distinct growth trajectory profiles that have differential risks for developing asthma.
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