Evidence map›Paper›PMID 34788634›Full record

ArticleCurrent biology : CB2022

Widespread introgression across a phylogeny of 155 Drosophila genomes.

Anton Suvorov, Bernard Y Kim, Jeremy Wang, Ellie E Armstrong, David Peede, Emmanuel R R D'Agostino, Donald K Price, Peter Waddell, Michael Lang, Virginie Courtier-Orgogozo and 5 more

Abstract read
In one paragraph

Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 174 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
174citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

174 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Updated Transposable Element Libraries forbioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Pervasive effects ofbioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Article
  10. Lifestyles ofProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Article
  12. Article
  13. Rapid floral syndrome convergence inbioRxiv : the preprint server for biology · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Temperature-sensitive cytoplasmic incompatibility across divergentbioRxiv : the preprint server for biology · 2026
    Article
  20. Article

114 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Anton SuvorovDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: antony.suvorov@med.unc.edu.
Bernard Y KimDepartment of Biology, Stanford University, Stanford, CA, USA.
Jeremy WangDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Ellie E ArmstrongDepartment of Biology, Stanford University, Stanford, CA, USA.
David PeedeDepartment of Biology, University of North Carolina, Chapel Hill, NC 27599, USA.
Emmanuel R R D'AgostinoDepartment of Biology, University of North Carolina, Chapel Hill, NC 27599, USA.
Donald K PriceSchool of Life Sciences, University of Nevada, Las Vegas, NV 89119, USA.
Peter WaddellSchool of Fundamental Sciences, Massey University, Palmerston North 4442, New Zealand.
Michael LangCNRS, Institut Jacques Monod, Université de Paris, Paris 75013, France.
Virginie Courtier-OrgogozoCNRS, Institut Jacques Monod, Université de Paris, Paris 75013, France.
Jean R DavidLaboratoire Evolution, Génomes, Comportement, Ecologie (EGCE) CNRS, IRD, Univ. Paris-sud, Université Paris-Saclay, Gif sur Yvette 91190, France; Institut de Systématique, Evolution, Biodiversité, CNRS, MNHN, UPMC, EPHE, Muséum National d'Histoire Naturelle, Sorbonne Universités, Paris 75005, France.
Dmitri PetrovDepartment of Biology, Stanford University, Stanford, CA, USA.
Daniel R MatuteDepartment of Biology, University of North Carolina, Chapel Hill, NC 27599, USA.
Daniel R SchriderDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Aaron A ComeaultMolecular Ecology & Evolution Group, School of Natural Sciences, Bangor University, Bangor, Gwynedd LL57 2DGA, UK. Electronic address: a.comeault@bangor.ac.uk.

Funding

Genomics of rapid adaptation in the lab and in the wildR35GM118165 · NIGMS · STANFORD UNIVERSITY · PI Dmitri Petrov · 2016 to 2026
$8.3M
Advancing evolutionary genetics through deep learningR35GM138286 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DANIEL R SCHRIDER · 2020 to 2026
$2.8M
The prevalence of genetic introgression in speciationR01GM121750 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MATUTE, DANIEL · 2017 to 2021
$1.7M
Predoctoral Training Program in Biological Data Science at Brown UniversityT32GM128596 · NIGMS · BROWN UNIVERSITY · PI RAMACHANDRAN, SOHINI, SANDSTEDE, BJORN · 2018 to 2022
$1.5M
Advanced sequencing as a novel diagnostic tool to discover strain-level variation and function of mucosal-adherent bacteria contributing to IBDK01DK119582 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WANG, JEREMY R · 2019 to 2023
$754k
Inferring selection from human population genomic dataR00HG008696 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SCHRIDER, DANIEL R · 2018 to 2020
$729k
A comparative population genomic approach for high-resolution inference of natural selection in fruit fliesF32GM135998 · NIGMS · STANFORD UNIVERSITY · PI KIM, BERNARD YOUNGSOO · 2020 to 2021
$131k
NHGRI NIH HHS R00 HG008696NIDDK NIH HHS K01 DK119582NIGMS NIH HHS F32 GM135998NIGMS NIH HHS R01 GM121750NIGMS NIH HHS R35 GM118165NIGMS NIH HHS R35 GM138286NIGMS NIH HHS T32 GM128596
6 · The paper itself

Abstract

Genome-scale sequence data have invigorated the study of hybridization and introgression, particularly in animals. However, outside of a few notable cases, we lack systematic tests for introgression at a larger phylogenetic scale across entire clades. Here, we leverage 155 genome assemblies from 149 species to generate a fossil-calibrated phylogeny and conduct multilocus tests for introgression across 9 monophyletic radiations within the genus Drosophila. Using complementary phylogenomic approaches, we identify widespread introgression across the evolutionary history of Drosophila. Mapping gene-tree discordance onto the phylogeny revealed that both ancient and recent introgression has occurred across most of the 9 clades that we examined. Our results provide the first evidence of introgression occurring across the evolutionary history of Drosophila and highlight the need to continue to study the evolutionary consequences of hybridization and introgression in this genus and across the tree of life.

Indexed as

DrosophilaGenomeAnimalsBiological EvolutionHybridization, GeneticPhylogenygene flowintrogressionphylogenetic discordancePhylogenomicsreticulate evolution

Identifiers

PMID34788634
PMCPMC8752469

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.