Evidence map›Paper›PMID 34788607›Full record

ArticleCell reports2021

Homer1a regulates Shank3 expression and underlies behavioral vulnerability to stress in a model of Phelan-McDermid syndrome.

Raozhou Lin, Lisa N Learman, M Ali Bangash, Tatiana Melnikova, Erica Leyder, Sai C Reddy, Nirinjini Naidoo, Joo Min Park, Alena Savonenko, Paul F Worley

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Raozhou LinSolomon Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205, USA.
Lisa N LearmanSolomon Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205, USA.
M Ali BangashSolomon Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205, USA; Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK.
Tatiana MelnikovaDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Erica LeyderDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Sai C ReddySolomon Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205, USA.
Nirinjini NaidooDivision of Sleep Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Joo Min ParkCenter for Cognition and Sociality, Institute for Basic Science, Daejeon 34126, Republic of Korea; University of Science and Technology, Daejeon 34113, Republic of Korea. Electronic address: joominp@ibs.re.kr.
Alena SavonenkoDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: asavone1@jhmi.edu.
Paul F WorleySolomon Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address: pworley@jhmi.edu.
Johns Hopkins University · USInstitute for Basic Science · KRUniversity of Pennsylvania · US

Funding

UNDERSTANDING NO SIGNALING RESULTING IN NEUROPROTECTION.P50DA000266 · NIDA · JOHNS HOPKINS UNIVERSITY · PI BARABAN, JAY M · 1985 to 2017
$45.2M
THE ROLE OF SLEEP IN MEMORY STORAGEP01AG017628 · NIA · UNIVERSITY OF PENNSYLVANIA · PI PACK, ALLAN I · 2001 to 2017
$19.2M
De novo Synthesis and MemoryR35NS097966 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WORLEY, PAUL F · 2017 to 2024
$4.3M
Dynamic regulation of Shank3 and ASDR01NS070301 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SAVONENKO, ALENA, WORLEY, PAUL F · 2009 to 2016
$3.7M
NIA NIH HHS P01 AG017628NIDA NIH HHS P50 DA000266NINDS NIH HHS R01 NS070301NINDS NIH HHS R35 NS097966
6 · The paper itself

Abstract

Mutations of SHANK3 cause Phelan-McDermid syndrome (PMS), and these individuals can exhibit sensitivity to stress, resulting in behavioral deterioration. Here, we examine the interaction of stress with genotype using a mouse model with face validity to PMS. In Shank3

Indexed as

AnimalsChromosome DeletionChromosome DisordersChromosomes, Human, Pair 22Disease Models, AnimalGene ExpressionGene Expression RegulationHomer Scaffolding ProteinsMaleMiceMice, Inbred C57BLMice, TransgenicMicrofilament ProteinsNerve Tissue ProteinsPhenotypePyramidal CellsHOMER1 protein, humanHomer Scaffolding ProteinsMicrofilament ProteinsNerve Tissue ProteinsSHANK3 protein, humanautismHomer1aNMDARPhelan-McDermid syndromeShank3social behaviorstresssynapse

Identifiers

PMID34788607
PMCPMC13034877
OpenAlexW3212813467

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.