ArticleImmunity2021
Ileitis-associated tertiary lymphoid organs arise at lymphatic valves and impede mesenteric lymph flow in response to tumor necrosis factor.
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Article in Immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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55citing papers in PubMed
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55 citing papers in PubMed, 73 citations in OpenAlex.
- Review
- Lymphatic Endothelial Cells in Health and Disease.MedComm · 2026Review
- Dysfunctional adipose tissue-lymphatic crosstalk in obesity.Nature reviews. Endocrinology · 2026Review
- The crosstalk between lymphatic endothelial cells and immune cells in Physiological and Pathological conditions.Cellular and molecular life sciences : CMLS · 2026Review
- Mesenteric adipose tissue: from protective gatekeeper to driver of inflammatory bowel disease.Immunometabolism (Cobham, Surrey) · 2026Review
- Multiomics study on the tertiary lymphatic structure signature of colon cancer.Translational cancer research · 2026Article
- Artery Tertiary Lymphoid Organs Form Neuroimmune Cardiovascular Interfaces in Atherosclerosis.Immunological reviews · 2026Review
- Molecular determinants of cardiac lymphatic dysfunction in a chronic pressure-overload model.EMBO molecular medicine · 2026Article
- Tertiary lymphoid structures are associated with lower axillary residual nodal burden in breast cancer patients after neoadjuvant chemotherapy.European journal of medical research · 2025Article
- Lung Lymphatics in Edema, Inflammation, and Thrombosis.Arteriosclerosis, thrombosis, and vascular biology · 2025Review
- 3D imaging and single-cell analysis reveal cellular heterogeneity of lymphatic valve endothelial cell types.iScience · 2025Article
- A Lymphatic Perspective on Obesity and Inflammatory Arthritis: New Disease-Modifying Potential in Rheumatology.Journal of clinical medicine · 2025Article
- Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells.bioRxiv : the preprint server for biology · 2025Article
- Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitis.Nature immunology · 2025Article
- Organ-specific features of human kidney lymphatics are disrupted in chronic transplant rejection.The Journal of clinical investigation · 2025Article
- S1PR1 regulates lymphatic valve development and tertiary lymphoid organ formation in the ileum.The Journal of experimental medicine · 2025Article
- Gene-environment interactions shape the host-microbial interface in inflammatory bowel disease.Nature immunology · 2025Review
- Lymphatic alterations in Crohn's disease: the villain or victim.American journal of physiology. Gastrointestinal and liver physiology · 2025Article
- Metabolic and Immune Crosstalk in Cardiovascular Disease.Circulation research · 2025Review
- Mesenteric Lymphatic B Cells Migrate to the Gut and Aggravate TNBS-Induced Rat Colitis via Regulating Intestinal T Cells.International journal of molecular sciences · 2025Article
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Authors and funding
16 authors at 3 institutions in 1 country.
Rafael S CzepielewskiDepartment of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Emma C ErlichDepartment of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Emily J OnuferDepartment of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Shannon YoungDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Brian T SaundersDepartment of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Yong-Hyun HanDepartment of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Mary WohltmannDepartment of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Peter L WangDepartment of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Ki-Wook KimDepartment of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Shashi KumarDepartment of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Chyi-Song HsiehDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Joshua P ScallanDepartment of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, USA.
Ying YangDepartment of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, USA.
Bernd H ZinselmeyerDepartment of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Michael J DavisDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA.
Gwendalyn J RandolphDepartment of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: gjrandolph@wustl.edu.
Washington University in St. Louis · USUniversity of South Florida · USUniversity of Missouri · US
Funding
Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Jeffrey Wade Brown · 2000 to 2026
$30.8MThe Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Fabio Cominelli · 2015 to 2026
$15.6MTRAINING PROGRAM IN IMMUNOLOGY AND IMMUNOGENETICST32AI007163 · NIAID · WASHINGTON UNIVERSITY · PI Kenneth M Murphy, Kodi S Ravichandran · 1985 to 2026
$14.8MPediatric Gastroenterology Research Training ProgramT32DK077653 · NIDDK · WASHINGTON UNIVERSITY · PI PHILLIP I TARR · 2007 to 2026
$5.8MDIFFERENTIATION AND FUNCTION OF MONOCYTES AND MACROPHAGESR37AI049653 · NIAID · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J · 2016 to 2025
$4.3MLymphatic remodeling and transport of dietary fats in short gut syndromeR01DK119147 · NIDDK · WASHINGTON UNIVERSITY · PI Bahaa Elgendy, Ajay K. Jain · 2019 to 2026
$4.0MINTEGRATING CELL & LIPOPROTEIN TRAFFICKING WITH VASCULAR BIOLOGY IN HUMAN IBDDP1DK109668 · NIDDK · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J · 2015 to 2019
$3.8MMechanisms that alter lymphatic transport in inflammatory bowel diseaseR01AI168044 · NIAID · WASHINGTON UNIVERSITY · PI Gwendalyn J Randolph · 2022 to 2026
$2.8MPathways Regulating Lymphatic Vessel Permeability and Valve FormationR01HL142905 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI SCALLAN, JOSHUA PAUL · 2019 to 2023
$2.2MRole of membrane-associated macrophages in health and inflammationR01DK126753 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KIM, KIWOOK · 2021 to 2025
$2.1MMolecular mechanisms enhancing lymphatic valve formationR01HL145397 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI YANG, YING · 2019 to 2023
$1.9MRole of bile acid receptors FXR and TGR5 in preventing injury in short bowel syndromeR01DK131136 · NIDDK · SAINT LOUIS UNIVERSITY · PI JAIN, AJAY K. · 2021 to 2025
$1.9MNHLBI NIH HHS R01 HL142905NHLBI NIH HHS R01 HL145397NIAID NIH HHS R01 AI168044NIAID NIH HHS R37 AI049653NIAID NIH HHS T32 AI007163NIDDK NIH HHS DP1 DK109668NIDDK NIH HHS DP1 DK126190NIDDK NIH HHS P30 DK052574NIDDK NIH HHS P30 DK097948NIDDK NIH HHS R01 DK119147NIDDK NIH HHS R01 DK126753NIDDK NIH HHS R01 DK131136NIDDK NIH HHS T32 DK077653
Abstract
Lymphangitis and the formation of tertiary lymphoid organs (TLOs) in the mesentery are features of Crohn's disease. Here, we examined the genesis of these TLOs and their impact on disease progression. Whole-mount and intravital imaging of the ileum and ileum-draining collecting lymphatic vessels (CLVs) draining to mesenteric lymph nodes from TNF
Indexed as
AnimalsCell MovementCells, CulturedCrohn DiseaseDisease Models, AnimalEndothelial CellsHumansIleitisIleumLymphLymphangitisLymphatic VesselsMesenteryMiceMice, KnockoutStress, MechanicalTumor Necrosis Factor-alphaCrohn’s diseasecytokine signalingendotheliuminflammationinflammatory bowel diseaselymphocyte migrationlympho-organogenesis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.