Evidence map›Paper›PMID 34788575›Full record

ReviewJournal of medicinal food2022

A Practical Perspective on the Use of Botanicals During the COVID-19 Pandemic: From Proven to Potential Interactions.

Alexander Bertuccioli, Marco Cardinali, Francesco Di Pierro, Simone Magi, Giordano Zonzini

Registry-linked trialOpen access · hybridAbstract readReview
In one paragraph

Review in Journal of medicinal food, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06183372 (A Randomised Double-blind Placebo-controlled Acute Trial of Encapsulated Lemon Balm Efficacy and Tolerance on Calmness and Mood During Periods of Cognitive Demand), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06183372 nacompletednot on this mapstarted 2023, after this paper: background citation

A Randomised Double-blind Placebo-controlled Acute Trial of Encapsulated Lemon Balm Efficacy and Tolerance on Calmness and Mood During Periods of Cognitive Demand

TypeinterventionalSponsorUniversity of ReadingRan2023 to 2024Enrolled123ConditionsStress, Mood DisturbanceArmsLemon balm, Placebo
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. The acute effects of Zensera™ (Therapeutic advances in psychopharmacology · 2026
    Article
  2. Role of Cytochrome P450 2C9 in COVID-19 Treatment: Current Status and Future Directions.European journal of drug metabolism and pharmacokinetics · 2023
    Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Alexander BertuccioliDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.ORCID 0000-0002-3922-9115
Marco CardinaliDepartment of Internal Medicine, Infermi Hospital, AUSL Romagna, Rimini, Italy.
Francesco Di PierroDigestive Endoscopy Unit and Gastroenterology, Fondazione Poliambulanza, Brescia, Italy.
Simone MagiItalian Association of Fitness e Medicine (AIFeM), Ravenna, Italy.
Giordano ZonziniItalian Association of Fitness e Medicine (AIFeM), Ravenna, Italy.
Italian Association for Cancer Research · ITOspedale Infermi di Rimini · ITUniversity of Urbino · ITVelleja Research · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this review, we examined the top 10 nutraceutical products sold in Italian pharmacies and parapharmacies as well as hypermarkets and supermarkets; in the first, three product categories saw the greatest increase in sales (vitamins and minerals, immunostimulants, and sleep products) for the 12-month period between October 2019 and October 2020 (including first pandemic wave of SARS-CoV-2). We are investigating their respective formulas and isolating the botanicals that are used to make them. Many of these products have undergone preclinical and clinical studies. We performed a systematic literature search in the MEDLINE database using PubMed and Google Scholar from November 15, 2020 to December 15, 2020 (including studies carried out between 1980 and 2020). The search terms that were used included the complete name of the medicinal plant in English or Latin and the terms "cytochrome" or "drug interactions," crossing, respectively, the Latin name and English common names with "cytochrome" and "drug interactions." The search included

Indexed as

COVID-19Plants, MedicinalRhodiolaAnimalsHumansPandemicsSARS-CoV-2botanicalsCOVID-19CYPcytochromenutraceuticalsSARS-CoV-2

Identifiers

PMID34788575
PMCPMC8787711
OpenAlexW3213381468

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.