ArticleACS nano2021
A Lipid-Based Droplet Processor for Parallel Chemical Signals.
Article in ACS nano, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The Power of Tiny Spaces.JACS Au · 2026Review
- Membrane-Associated Biomolecules for Synthetic Cell Signalling.Chembiochem : a European journal of chemical biology · 2026Review
- Prototissues: Assembly strategies, collective behaviors, and emerging applications.Bioactive materials · 2026Review
- Light-controlled synthetic communication networks via paired connexon nanopores.Nature communications · 2025Article
- High-Resolution Patterned Delivery of Chemical Signals From 3D-Printed Picoliter Droplet Networks.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Programmed Fabrication of Vesicle-Based Prototissue Fibers with Modular Functionalities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Manipulation of encapsulated artificial phospholipid membranes using sub-micellar lysolipid concentrations.Communications chemistry · 2024Article
- Reconfigurable droplet networks.Nature communications · 2024Article
- Interlinking spatial dimensions and kinetic processes in dissipative materials to create synthetic systems with lifelike functionality.Nature nanotechnology · 2024Review
- Article
- Toward droplets displaying life-like interaction behaviors.Biomicrofluidics · 2023Article
- Challenges and opportunities in achieving the full potential of droplet interface bilayers.Nature chemistry · 2022Review
- Building programmable multicompartment artificial cells incorporating remotely activated protein channels using microfluidics and acoustic levitation.Nature communications · 2022Article
- Droplets in underlying chemical communication recreate cell interaction behaviors.Nature communications · 2022Article
- Chemical Communication in Artificial Cells: Basic Concepts, Design and Challenges.Frontiers in molecular biosciences · 2022Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
A key goal of bottom-up synthetic biology is to construct cell- and tissue-like structures. Underpinning cellular life is the ability to process several external chemical signals, often in parallel. Until now, cell- and tissue-like structures have been constructed with no more than one signaling pathway. Many pathways rely on signal transport across membranes using protein nanopores. However, such systems currently suffer from the slow transport of molecules. We have optimized the application of these nanopores to permit fast molecular transport, which has allowed us to construct a processor for parallel chemical signals from the bottom up in a modular fashion. The processor comprises three aqueous droplet compartments connected by lipid bilayers and operates in an aqueous environment. It can receive two chemical signals from the external environment, process them orthogonally, and then produce a distinct output for each signal. It is suitable for both sensing and enzymatic processing of environmental signals, with fluorescence and molecular outputs. In the future, such processors could serve as smart drug delivery vehicles or as modules within synthetic tissues to control their behavior in response to external chemical signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.