Evidence map›Paper›PMID 34788501›Full record

ArticleChembiochem : a European journal of chemical biology2022

Galacto-Oligosaccharide Supplementation Modulates Pathogen-Commensal Competition between Streptococcus agalactiae and Streptococcus salivarius.

Rebecca E Moore, Harrison C Thomas, Shannon D Manning, Jennifer A Gaddy, Steven D Townsend

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Rebecca E MooreDepartment of Chemistry, Vanderbilt University, 37235, Nashville, Tennessee, USA.
Harrison C ThomasDepartment of Chemistry, Vanderbilt University, 37235, Nashville, Tennessee, USA.
Shannon D ManningDepartment of Microbiology and Molecular Genetics, Michigan State University, 48824, East Lansing, Michigan, USA.
Jennifer A GaddyTennessee Valley Healthcare Systems, Department of Veterans Affairs, 37212, Nashville, Tennessee, USA.ORCID 0000-0002-2192-4224
Steven D TownsendDepartment of Chemistry, Vanderbilt University, 37235, Nashville, Tennessee, USA.ORCID 0000-0001-5362-7235
Vanderbilt University · USMichigan State University · USVA Tennessee Valley Healthcare System · US

Funding

Determining the contribution of zinc deficiency to perinatal Group B Streptococcus infectionsR01HD090061 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ARONOFF, DAVID M, GADDY, JENNIFER A · 2017 to 2021
$2.5M
Toxicant Exposure Impacts Host-pathogen interactions within the Reproductive TractI01BX005352 · VA · VETERANS HEALTH ADMINISTRATION · PI GADDY, JENNIFER A · 2021 to 2024
–
BLRD VA I01 BX005352College of Arts & Science at Vanderbilt UniversityNational Science Foundation 1847804NICHD NIH HHS R01 HD090061
6 · The paper itself

Abstract

The members of the infant microbiome are governed by feeding method (breastmilk vs. formula). Regardless of the source of nutrition, a competitive growth advantage can be provided to commensals through prebiotics - either human milk oligosaccharides (HMOs) or plant oligosaccharides that are supplemented into formula. To characterize how prebiotics modulate commensal - pathogen interactions, we have designed and studied a minimal microbiome where a pathogen, Streptococcus agalactiae engages with a commensal, Streptococcus salivarius. We discovered that while S. agalactiae suppresses the growth of S. salivarius via increased lactic acid production, galacto-oligosaccharides (GOS) supplementation reverses the effect. This result has major implications in characterizing how single species survive in the gut, what niche they occupy, and how they engage with other community members.

Indexed as

PrebioticsDietary SupplementsGastrointestinal MicrobiomeHumansLactic AcidMilk, HumanOligosaccharidesStreptococcus agalactiaeStreptococcus salivariusLactic AcidOligosaccharidesPrebiotics

Identifiers

PMID34788501
PMCPMC9197176
OpenAlexW3211830772

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.