Evidence map›Paper›PMID 34788462›Full record

ArticlePain medicine (Malden, Mass.)2021

Consensus practice guidelines on interventions for cervical spine (facet) joint pain from a multispecialty international working group.

Robert W Hurley, Meredith C B Adams, Meredith Barad, Arun Bhaskar, Anuj Bhatia, Andrea Chadwick, Timothy R Deer, Jennifer Hah, W Michael Hooten, Narayan R Kissoon and 12 more

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Pain medicine (Malden, Mass.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07535515 (Comparative Effectiveness of Cervical Zygapophyseal Joint Radiofrequency Versus Anterior Cervical Discectomy and Fusion in Chronic Post-Traumatic Whiplash), which is not on this map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07535515 completednot on this map

Comparative Effectiveness of Cervical Zygapophyseal Joint Radiofrequency Versus Anterior Cervical Discectomy and Fusion in Chronic Post-Traumatic Whiplash: A Retrospective Cohort Study

TypeobservationalSponsorUniversity of ValenciaRan2005 to 2025Enrolled170ConditionsWhiplash Injury, Whiplash Injury of Cervical Spine, Chronic Neck Pain, Post-Traumatic Neck Pain
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Article
  5. Review
  6. Review
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  15. Scapular pain in cervical radiculopathy: A scoping review.North American Spine Society journal · 2025
    Review
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  17. Article
  18. Article
  19. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 18 institutions in 5 countries.

Robert W HurleyAnesthesiology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Meredith C B AdamsAnesthesiology, Wake Forest Baptist Health, Winston-Salem, North Carolina, USA.ORCID 0000-0002-3969-4279
Meredith BaradAnesthesiology, Perioperative and Pain Medicine, Stanford Hospital and Clinics, Redwood City, California, USA.
Arun BhaskarAnesthesiology, Imperial College Healthcare NHS Trust Haemodialysis Clinic, Hayes Satellite Unit, Hayes, UK.
Anuj BhatiaAnesthesia and Pain Management, University of Toronto and University Health Network - Toronto Western Hospital, Toronto, Ontario, Canada.ORCID 0000-0001-6292-8654
Andrea ChadwickAnesthesiology, University of Kansas Medical Center, Kansas City, Kansas, USA.ORCID 0000-0002-0570-9997
Timothy R DeerSpine and Nerve Center of the Virginias, West Virginia University - Health Sciences Campus, Morgantown, West Virginia, USA.ORCID 0000-0001-8907-7730
Jennifer HahAnesthesiology, Stanford University School of Medicine, Palo Alto, California, USA.
W Michael HootenAnesthesiology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0001-5645-6355
Narayan R KissoonNeurology, Mayo Clinic, Rochester, New York, USA.
David Wonhee LeeFullerton Orthopaedic Surgery Medical Group, Fullerton, California, USA.
Zachary MccormickPhysical Medicine and Rehabilitation, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Jee Youn MoonAnesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul, South Korea.ORCID 0000-0001-5551-7750
Samer NarouzeCenter for Pain Medicine, Summa Western Reserve Hospital, Cuyahoga Falls, Ohio, USA.ORCID 0000-0003-1849-1402
David A ProvenzanoPain Diagnostics and Interventional Care, Sewickley, Pennsylvania, USA.
Byron J SchneiderPhysical Medicine and Rehabilitation, Vanderbilt University, Nashville, Tennessee, USA.
Maarten van EerdAnesthesiology, Maastricht University Medical Centre, Maastricht, Limburg, The Netherlands.
Jan Van ZundertAnesthesiology, Maastricht University Medical Centre, Maastricht, Limburg, The Netherlands.
Mark S WallaceAnesthesiology, UCSD Medical Center - Thornton Hospital, San Diego, California, USA.
Sara M WilsonAnesthesia, WRNMMC, Bethesda, Maryland, USA.
Zirong ZhaoNeurology, VA Healthcare Center District of Columbia, Washington, District of Columbia, USA.
Steven P CohenAnesthesia, WRNMMC, Bethesda, Maryland, USA.ORCID 0000-0001-5928-2127
Maastricht University Medical Centre · NLMayo Clinic · USAtrium Health Wake Forest Baptist · USFullerton College · USImperial College Healthcare NHS Trust · GBJohns Hopkins University · USSeoul National University · KRStanford Health Care · USStanford University · USUniversity Health Network · CAUniversity of Kansas Medical Center · USUniversity of Utah · USVanderbilt University · USWake Forest University · USWalter Reed National Military Medical Center · USWashington DC VA Medical Center · USWestern Reserve Hospital · USWest Virginia University · US

Funding

Central Nervous System Amplification in Lumbar Failed Back Surgery SyndromeK23GM123320 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI CHADWICK, ANDREA LYNN · 2017 to 2022
$1.1M
Identifying opioid response phenotypes in low back pain electronic health dataK08EB022631 · NIBIB · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ADAMS, MEREDITH C. B. · 2017 to 2020
$737k
Workforce Innovation in Data Science, Education, and Addiction Research (WISER)R25DA061740 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MEREDITH C. B. ADAMS, Amber Keller Brooks · 2024 to 2026
$405k
NIAMS NIH HHS L30 AR074165NIBIB NIH HHS K08 EB022631NIDA NIH HHS R25 DA061740NIGMS NIH HHS K23 GM123320
6 · The paper itself

Abstract

backgroundThe past two decades have witnessed a surge in the use of cervical spine joint procedures including joint injections, nerve blocks and radiofrequency ablation to treat chronic neck pain, yet many aspects of the procedures remain controversial.

methodsIn August 2020, the American Society of Regional Anesthesia and Pain Medicine and the American Academy of Pain Medicine approved and charged the Cervical Joint Working Group to develop neck pain guidelines. Eighteen stakeholder societies were identified, and formal request-for-participation and member nomination letters were sent to those organizations. Participating entities selected panel members and an ad hoc steering committee selected preliminary questions, which were then revised by the full committee. Each question was assigned to a module composed of 4-5 members, who worked with the Subcommittee Lead and the Committee Chairs on preliminary versions, which were sent to the full committee after revisions. We used a modified Delphi method whereby the questions were sent to the committee en bloc and comments were returned in a non-blinded fashion to the Chairs, who incorporated the comments and sent out revised versions until consensus was reached. Before commencing, it was agreed that a recommendation would be noted with >50% agreement among committee members, but a consensus recommendation would require ≥75% agreement.

resultsTwenty questions were selected, with 100% consensus achieved in committee on 17 topics. Among participating organizations, 14 of 15 that voted approved or supported the guidelines en bloc, with 14 questions being approved with no dissensions or abstentions. Specific questions addressed included the value of clinical presentation and imaging in selecting patients for procedures, whether conservative treatment should be used before injections, whether imaging is necessary for blocks, diagnostic and prognostic value of medial branch blocks and intra-articular joint injections, the effects of sedation and injectate volume on validity, whether facet blocks have therapeutic value, what the ideal cut-off value is for designating a block as positive, how many blocks should be performed before radiofrequency ablation, the orientation of electrodes, whether larger lesions translate into higher success rates, whether stimulation should be used before radiofrequency ablation, how best to mitigate complication risks, if different standards should be applied to clinical practice and trials, and the indications for repeating radiofrequency ablation.

conclusionsCervical medial branch radiofrequency ablation may provide benefit to well-selected individuals, with medial branch blocks being more predictive than intra-articular injections. More stringent selection criteria are likely to improve denervation outcomes, but at the expense of false-negatives (ie, lower overall success rate). Clinical trials should be tailored based on objectives, and selection criteria for some may be more stringent than what is ideal in clinical practice.

Indexed as

Chronic PainZygapophyseal JointArthralgiaCervical VertebraeHumansInjections, Intra-ArticularAtlantoaxialAtlantooccipitalFacet JointNeck PainRadiofrequencyZygapophyseal

Identifiers

PMID34788462
PMCPMC8633772
OpenAlexW3211351045

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.