Evidence map›Paper›PMID 34788385›Full record

ArticleBlood2022

DNMT3A overgrowth syndrome is associated with the development of hematopoietic malignancies in children and young adults.

Margaret A Ferris, Amanda M Smith, Sharon E Heath, Eric J Duncavage, Matthew Oberley, David Freyer, Robert Wynn, Sofia Douzgou, John M Maris, Anne F Reilly and 8 more

Open access · hybridAbstract readLetter
In one paragraph

Article in Blood, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Melanoma in a patient with DNMT3A overgrowth syndrome.Cold Spring Harbor molecular case studies · 2023
    Article
  9. Article
  10. Genetic Predisposition to Hematologic Malignancies in Childhood and Adolescence.Mediterranean journal of hematology and infectious diseases · 2023
    Review
  11. Article
  12. Clonal Hematopoiesis: Role in Hematologic and Non-Hematologic Malignancies.Mediterranean journal of hematology and infectious diseases · 2022
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 10 institutions in 4 countries.

Margaret A FerrisDepartment of Pediatrics.ORCID 0000-0002-0577-2523
Amanda M SmithDepartment of Medicine, and.ORCID 0000-0002-8716-6745
Sharon E HeathDepartment of Medicine, and.
Eric J DuncavageDepartment of Pathology and Immunology, Washington University, St Louis, MO.
Matthew OberleyCaris Life Sciences, Phoenix, AZ.ORCID 0000-0001-6419-2513
David FreyerChildren's Hospital Los Angeles, Los Angeles, CA.ORCID 0000-0001-5280-990X
Robert WynnPaediatric Haematology and Bone Marrow Transplant (BMT), Royal Manchester Children's Hospital, Manchester, United Kingdom.
Sofia DouzgouDepartment of Medical Genetics, Haukeland University Hospital, Bergen, Norway.ORCID 0000-0001-8890-7544
John M MarisChildren's Hospital of Philadelphia, Philadelphia, PA and.ORCID 0000-0002-8088-7929
Anne F ReillyChildren's Hospital of Philadelphia, Philadelphia, PA and.ORCID 0000-0002-0523-7600
Melinda D WuDivision of Pediatric Hematology/Oncology, Department of Pediatrics, Oregon Health & Science University, Portland, OR.
Florence ChooDivision of Pediatric Hematology/Oncology, Department of Pediatrics, Oregon Health & Science University, Portland, OR.ORCID 0000-0002-7904-8271
Roel B FietsDepartment of Internal Medicine, Amphia Hospital, Breda, The Netherlands; and.
Saskia KoeneDepartment of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-9876-744X
David H SpencerDepartment of Medicine, and.ORCID 0000-0002-5314-3043
Christopher A MillerDepartment of Medicine, and.ORCID 0000-0003-4266-6700
Marwan ShinawiDepartment of Pediatrics.ORCID 0000-0003-1329-4100
Timothy J LeyDepartment of Medicine, and.ORCID 0000-0002-9913-0520
Children's Hospital of Philadelphia · USOregon Health & Science University · USPediatrics and Genetics · USAmphia Ziekenhuis · NLCaris Life Sciences (United States) · USChildren's Hospital of Los Angeles · USHaukeland University Hospital · NOLeiden University Medical Center · NLRoyal Manchester Children's Hospital · GBWashington University in St. Louis · US

Funding

Specimen Acquistition and Expression ProfilingP01CA101937 · NCI · WASHINGTON UNIVERSITY · PI LEY, TIMOTHY J. · 2003 to 2023
$58.8M
Molecular Pathogenesis of Acute Myeloid LeukemiaR35CA197561 · NCI · WASHINGTON UNIVERSITY · PI Timothy J. Ley · 2015 to 2026
$11.0M
Discovering mechanisms of neuroblastoma tumorigenesis to improve patient outcomesR35CA220500 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI JOHN M MARIS · 2017 to 2026
$8.7M
Child Health Research CenterK12HD076224 · NICHD · WASHINGTON UNIVERSITY · PI MARK E. LOWE · 2013 to 2026
$6.2M
Dysregulated genome architecture in acute myeloid leukemiaR37CA259359 · NCI · WASHINGTON UNIVERSITY · PI David H Spencer · 2022 to 2026
$1.8M
COMPREHENSIVE INFORMATIC ANALYSES OF AML GENOMES AND EPIGENOMESR50CA211782 · NCI · WASHINGTON UNIVERSITY · PI Christopher A Miller · 2017 to 2026
$1.5M
NCI NIH HHS P01 CA101937NCI NIH HHS R35 CA197561NCI NIH HHS R35 CA220500NCI NIH HHS R37 CA259359NCI NIH HHS R50 CA211782NICHD NIH HHS K12 HD076224
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

MutationAdolescentAdultChildChild, PreschoolCongenital AbnormalitiesDNA Methyltransferase 3AFemaleGerm-Line MutationHematologic NeoplasmsHumansMaleSyndromeYoung AdultDNA Methyltransferase 3ADNMT3A protein, human

Identifiers

PMID34788385
PMCPMC8777205
OpenAlexW3214640917

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.