Evidence map›Paper›PMID 34788338›Full record

ArticlePloS one2021

Cost-effectiveness analysis protocol of the Smart Triage program: A point-of-care digital triage platform for pediatric sepsis in Eastern Uganda.

Edmond C K Li, Sela Grays, Abner Tagoola, Clare Komugisha, Annette Mary Nabweteme, J Mark Ansermino, Craig Mitton, Niranjan Kissoon, Asif R Khowaja

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04304235 (Smart Triage), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04304235 nacompletednot on this map

Smart Triage: Triage and Management of Sepsis in Children Using the Point-of-care Paediatric Rapid Sepsis Trigger (PRST) Tool

TypeinterventionalSponsorUniversity of British ColumbiaRan2020 to 2023Enrolled18,693ConditionsSepsis, InfectionArmsPediatric Rapid Sepsis Trigger (PRST) tool, Emergency Triage and Treatment (ETAT) guidelines
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Edmond C K LiSchool of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
Sela GraysDepartment of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-6982-373X
Abner TagoolaJinja Regional Referral Hospital, Jinja, Uganda.
Clare KomugishaWalimu, Coral Crescent, Kololo, Kampala, Uganda.
Annette Mary NabwetemeWalimu, Coral Crescent, Kololo, Kampala, Uganda.
J Mark AnserminoDepartment of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.
Craig MittonSchool of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
Niranjan KissoonDepartment of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.
Asif R KhowajaFaculty of Applied Health Sciences, Brock University, St. Catharines, Canada.
University of British Columbia · CABrock University · CAJinja Hospital · UGVancouver Coastal Health · CA

Funding

Wellcome TrustWellcome Trust 215695/B/19/Z
6 · The paper itself

Abstract

backgroundSepsis is a clinical syndrome characterized by organ dysfunction due to presumed or proven infection. Severe cases can have case fatality ratio 25% or higher in low-middle income countries, but early diagnosis and timely treatment have a proven benefit. The Smart Triage program in Jinja Regional Referral Hospital in Uganda will provide expedited sepsis treatment in children through a data-driven electronic patient triage system. To complement the ongoing Smart Triage interventional trial, we propose methods for a concurrent cost-effectiveness analysis of the Smart Triage platform.

methodsWe will use a decision-analytic model taking a societal perspective, combining government and out-of-pocket costs, as patients bear a sizeable portion of healthcare costs in Uganda due to the lack of universal health coverage. Previously published secondary data will be used to link healthcare utilization with costs and intermediate outcomes with mortality. We will model uncertainty via probabilistic sensitivity analysis and present findings at various willingness-to-pay thresholds using a cost-effectiveness acceptability curve. DISCUSSION: Our proposed analysis represents a first step in evaluating the cost-effectiveness of an innovative digital triage platform designed to improve clinical outcomes in pediatric sepsis through expediting care in low-resource settings. Our use of a decision analytic model to link secondary costing data, incorporate post-discharge healthcare utilization, and model clinical endpoints is also novel in the pediatric sepsis triage literature for low-middle income countries. Our analysis, together with subsequent analyses modelling budget impact and scale up, will inform future modifications to the Smart Triage platform, as well as motivate scale-up to the district and national levels.

trial registrationTrial registration of parent clinical trial: NCT04304235, https://clinicaltrials.gov/ct2/show/NCT04304235. Registered 11 March 2020.

Indexed as

Cost-Benefit AnalysisSepsisTriageChildChild, PreschoolHealth Care CostsHumansPoint-of-Care SystemsUganda

Identifiers

PMID34788338
PMCPMC8598020
OpenAlexW3213861477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.