Evidence map›Paper›PMID 34788323›Full record

ArticlePloS one2021

Recent infections among individuals with a new HIV diagnosis in Rwanda, 2018-2020.

Gallican N Rwibasira, Samuel S Malamba, Gentille Musengimana, Richard C M Nkunda, Jared Omolo, Eric Remera, Vedaste Masengesho, Valens Mbonitegeka, Tafadzwa Dzinamarira, Eugenie Kayirangwa and 1 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

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  10. Lived Experiences of Adolescents with HIV in Rwanda: A Phenomenology Study.Rwanda journal of medicine and health sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Gallican N RwibasiraMailman School of Public Health, International Centre for AIDS care and Treatment program (ICAP) at Columbia University, Kigali, Rwanda.
Samuel S MalambaDivision of Global HIV/AIDS & TB, Centers for Global Health, US Centers for Disease Control and Prevention, City of Kigali, Rwanda.
Gentille MusengimanaDepartment of HIV, AIDS, Diseases prevention and Control, Division of HIV, STI, Viral Hepatitis and Other Viral Diseases Control, Ministry of Health, Rwanda Biomedical Centre (RBC), Kigali, Rwanda.ORCID 0000-0002-9552-3298
Richard C M NkundaDivision of Global HIV/AIDS & TB, Centers for Global Health, US Centers for Disease Control and Prevention, City of Kigali, Rwanda.
Jared OmoloDivision of Global HIV/AIDS & TB, Centers for Global Health, US Centers for Disease Control and Prevention, City of Kigali, Rwanda.
Eric RemeraDepartment of HIV, AIDS, Diseases prevention and Control, Division of HIV, STI, Viral Hepatitis and Other Viral Diseases Control, Ministry of Health, Rwanda Biomedical Centre (RBC), Kigali, Rwanda.
Vedaste MasengeshoMailman School of Public Health, International Centre for AIDS care and Treatment program (ICAP) at Columbia University, Kigali, Rwanda.
Valens MbonitegekaDepartment of HIV, AIDS, Diseases prevention and Control, Division of HIV, STI, Viral Hepatitis and Other Viral Diseases Control, Ministry of Health, Rwanda Biomedical Centre (RBC), Kigali, Rwanda.
Tafadzwa DzinamariraMailman School of Public Health, International Centre for AIDS care and Treatment program (ICAP) at Columbia University, Kigali, Rwanda.
Eugenie KayirangwaDivision of Global HIV/AIDS & TB, Centers for Global Health, US Centers for Disease Control and Prevention, City of Kigali, Rwanda.
Placidie MugwanezaDepartment of HIV, AIDS, Diseases prevention and Control, Division of HIV, STI, Viral Hepatitis and Other Viral Diseases Control, Ministry of Health, Rwanda Biomedical Centre (RBC), Kigali, Rwanda.
Rwanda Biomedical Center · RWUniversity of Global Health Equity · RW

Funding

PEPFAR
6 · The paper itself

Abstract

backgroundDespite Rwanda's progress toward HIV epidemic control, 16.2% of HIV-positive individuals are unaware of their HIV positive status. Tailoring the public health strategy could help reach these individuals with new HIV infection and achieve epidemic control. Recency testing is primarily for surveillance, monitoring, and evaluation but it's not for diagnostic purposes. However, it's important to know what proportion of the newly diagnosed are recent infections so that HIV prevention can be tailored to the profile of people who are recently infected. We therefore used available national data to characterize individuals with recent HIV infection in Rwanda to inform the epidemic response.

methodsWe included all national-level data for recency testing reported from October 2018 to June 2020. Eligible participants were adults (aged ≥15 years) who had a new HIV diagnosis, who self-reported being antiretroviral therapy (ART) naïve, and who had consented to recency testing. Numbers and proportions of recent HIV infections were estimated, and precision around these estimates was calculated with 95% confidence intervals (CI). Logistic regression was used to assess factors associated with being recently (within 12 months) infected with HIV.

resultsOf 7,785 eligible individuals with a new HIV-positive diagnosis, 475 (6.1%) met the criteria for RITA recent infection. The proportion of RITA recent infections among individuals with newly identified HIV was high among those aged 15-24 years (9.6%) and in men aged ≥65 years (10.3%) compared to other age groups; and were higher among women (6.7%) than men (5.1%). Of all recent cases, 68.8% were women, and 72.2% were aged 15-34 years. The Northern province had the fewest individuals with newly diagnosed HIV but had the highest proportion of recent infections (10.0%) compared to other provinces. Recent infections decreased by 19.6% per unit change in time (measured in months). Patients aged ≥25 years were less likely to have recent infection than those aged 15-24 years with those aged 35-49 years being the least likely to have recent infection compared to those aged 15-24 years (adjusted odds ratio [aOR], 0.415 [95% CI: 0.316-0.544]).

conclusionPublic health surveillance targeting the areas and the identified groups with high risk of recent infection could help improve outcomes.

Indexed as

AdolescentAdultAgedAlgorithmsAnti-Retroviral AgentsCross-Sectional StudiesFemaleHIV InfectionsHumansLogistic ModelsMaleMiddle AgedOdds RatioRetrospective StudiesRwandaYoung AdultAnti-Retroviral Agents

Identifiers

PMID34788323
PMCPMC8598012
OpenAlexW3213635691

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.